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Impact Factor: Unraveling the Significance of Redox Biology Research
Introduction:
The field of redox biology, exploring the intricate roles of oxidation and reduction reactions in biological systems, is exploding with groundbreaking discoveries. Understanding the impact factor of journals publishing this research is crucial for researchers, funders, and anyone wanting to navigate this rapidly evolving scientific landscape. This comprehensive guide dives deep into the world of redox biology impact factors, explaining what they mean, how they're calculated, their limitations, and their ultimate impact on the advancement of scientific knowledge. We'll explore the top journals in the field and offer strategies for maximizing your research's visibility and impact.
What is Redox Biology?
Before diving into impact factors, let's briefly define redox biology. It's the study of redox reactions – the transfer of electrons between molecules – within biological systems. These reactions are fundamental to numerous cellular processes, including energy production (mitochondrial respiration), cellular signaling, gene expression, and immune response. Imbalances in redox homeostasis, often leading to oxidative stress, are implicated in a wide array of diseases, from cancer and neurodegenerative disorders to cardiovascular disease and aging.
Understanding Impact Factors: A Deep Dive
The impact factor (IF) is a metric used to evaluate the relative importance and influence of academic journals. It's calculated by dividing the number of citations received by articles published in a particular journal during a specific period (typically the past two years) by the total number of articles published in that journal during the same period. A higher impact factor generally suggests that the journal publishes highly cited, influential research.
Limitations of Impact Factor in Redox Biology:
While the impact factor provides a useful benchmark, it's crucial to acknowledge its limitations:
Journal Specificity: Impact factors vary widely across disciplines. Comparing impact factors across different fields (e.g., comparing redox biology to particle physics) is inherently flawed.
Citation Bias: Certain research areas attract more citations than others, regardless of their intrinsic merit. Highly impactful, groundbreaking research in a niche area might not accumulate as many citations as incremental work in a more established, highly-cited field.
Publication Time Lag: The impact factor reflects past performance. A new, highly impactful journal might have a low initial IF, while an older journal with declining quality might still boast a relatively high IF based on past citations.
Gaming the System: While rare, some questionable practices exist to artificially inflate a journal's impact factor.
Top Journals in Redox Biology and their Impact Factors (Illustrative, not exhaustive):
Determining precise current impact factors requires consulting recent Journal Citation Reports (JCR) from Clarivate Analytics. However, journals consistently ranked high in redox biology-related research often include (but are not limited to):
Free Radical Biology and Medicine: This journal consistently ranks high and publishes a broad range of research on oxidative stress, antioxidants, and redox signaling.
Redox Biology: A highly-specialized journal focused on the fundamental mechanisms and implications of redox biology.
Antioxidants & Redox Signaling: Covers various aspects of antioxidant defense systems and their role in health and disease.
Biochemical Journal: While broader in scope, it publishes significant research relevant to redox biology.
Cellular and Molecular Life Sciences: Similar to the Biochemical Journal, it publishes impactful research with significant overlap in the redox biology field.
Strategies for Maximizing Research Impact in Redox Biology:
Beyond journal selection, researchers can take several steps to increase the impact of their work:
Rigorous Research Design: Well-designed, methodologically sound studies are more likely to be cited.
Clear Communication: Presenting results clearly and concisely in a compelling narrative is crucial.
Effective Dissemination: Actively engage with the scientific community by presenting your research at conferences, engaging in social media, and actively seeking collaborations.
Open Access Publishing: Open access articles are more widely accessible and potentially receive more citations.
The Future of Redox Biology and its Impact Factor Landscape:
Redox biology is a rapidly evolving field. New techniques and technologies are constantly being developed, leading to a greater understanding of redox processes in health and disease. This continuous innovation will likely reshape the landscape of journals and influence impact factor trends. We can expect to see increased specialization within the field, leading to the emergence of new journals focused on specific aspects of redox biology, each with its own evolving impact factor.
Book Outline: "Navigating the Redox Biology Research Landscape"
Author: Dr. Anya Sharma, PhD
Introduction: Defining redox biology and its significance; overview of the book's content.
Chapter 1: The Fundamentals of Redox Biology: Key concepts, mechanisms, and significance of redox reactions in biological systems.
Chapter 2: Redox Biology and Disease: The role of redox imbalance in various diseases (cancer, neurodegenerative disorders, cardiovascular disease, etc.).
Chapter 3: Impact Factor and Journal Selection: Understanding impact factors, their limitations, and strategies for selecting appropriate journals.
Chapter 4: Maximizing Research Impact: Strategies for designing, conducting, and disseminating high-impact research.
Chapter 5: Future Trends in Redox Biology Research: Emerging technologies, research areas, and their potential impact.
Conclusion: Summarizing key takeaways and emphasizing the ongoing importance of redox biology research.
Detailed Explanation of Book Chapters:
(Note: This section provides a detailed description of each chapter, mimicking the in-depth content expected in a full book.)
(Detailed explanations for each chapter would follow here, each spanning several hundred words. Due to word count limitations, I cannot include the full detailed explanation of all chapters. The above provides the framework for such an explanation.)
FAQs:
1. What is the average impact factor for redox biology journals? There's no single average; it varies significantly depending on the journal's specific focus and publication history. Consult the latest JCR data for up-to-date information.
2. Is a high impact factor always indicative of high-quality research? No. Impact factors have limitations and shouldn't be the sole criterion for judging research quality.
3. How are impact factors calculated? By dividing the number of citations received by articles published in a journal over a specific period by the total number of articles published during that period.
4. Can I game the impact factor system? Attempts to artificially inflate impact factors are unethical and may have serious consequences.
5. What are some alternative metrics for evaluating research impact? Altmetrics (social media mentions, downloads, etc.) can offer a more comprehensive picture.
6. What are some strategies for increasing my chances of publication in a high-impact factor journal? Focus on rigorous research design, clear writing, and effective dissemination.
7. How does open access publishing affect impact factors? Open access articles may potentially receive more citations due to increased accessibility.
8. How often are impact factors updated? Annually, typically based on data from the preceding two years.
9. What is the role of redox biology in aging research? Oxidative stress and redox imbalance are strongly implicated in the aging process, making it a key area of investigation in gerontology.
Related Articles:
1. Oxidative Stress and Cancer: A Redox Perspective: Discusses the role of redox imbalance in cancer development and progression.
2. Redox Signaling in the Cardiovascular System: Explores the intricate redox signaling pathways regulating cardiovascular function.
3. Antioxidants and their Efficacy in Human Health: Examines the potential benefits and limitations of antioxidant supplementation.
4. The Role of Mitochondria in Redox Homeostasis: Focuses on the mitochondria's central role in cellular redox balance.
5. Redox Biology of Neurodegenerative Diseases: Explores the involvement of redox processes in Alzheimer's, Parkinson's, etc.
6. Emerging Technologies in Redox Biology Research: Highlights innovative techniques used to study redox reactions.
7. Redox Regulation of Gene Expression: Discusses how redox signaling impacts gene transcription and translation.
8. The Impact of Environmental Factors on Redox Homeostasis: Examines the effects of pollution and other environmental factors on cellular redox balance.
9. Redox Biology and the Immune System: Investigates the critical role of redox reactions in immune function and response.
| impact factor redox biology: Redox Biology in Plasma Medicine Sander Bekeschus, Thomas von Woedtke, 2024-07-12 Plasma medicine uses non-equilibrium plasmas generated under atmospheric-pressure conditions. Therapeutical plasmas can stimulate tissue regeneration or inactivate cancer cells. This book reviews the interrelation between plasma chemistry and biochemistry complemented by discussion of the ways plasmas inactivate various pathogens. Focus is on the plasma effects on mammalian cells, subsequent consequences for cell-biological processes, and plasma applicability specific medical therapies. Contributions illustrate the ways cold atmospheric-pressure plasma can be used as a controllable source of redox-active species and as a useful tool for research in redox biology. Key Features Summarizes plasma chemistry, biochemistry, and microbiology Documents the ways plasmas interact with lipids, membranes, and cells Reviews therapeutic uses of plasmas in medicine Focuses on uses of plasmas as cancer treatment |
| impact factor redox biology: Guide for the Care and Use of Laboratory Animals National Research Council, Division on Earth and Life Studies, Institute for Laboratory Animal Research, Committee for the Update of the Guide for the Care and Use of Laboratory Animals, 2011-01-27 A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates. |
| impact factor redox biology: Oxidative Stress Helmut Sies, 2019-11-07 Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections: - A conceptual framework for studying oxidative stress. - Processes and oxidative stress responses. Signaling in major enzyme systems (oxidative eustress), and damaging modification of biomolecules (oxidative distress). - The exposome addresses lifelong exposure and impact on health, nutrient sensing, exercise and environmental pollution. - Health and disease processes, including ischemia-reperfusion injury, developmental and psychological disorders, hepatic encephalopathy, skeletal muscle disorders, pulmonary disease, gut disease, organ fibrosis, and cancer. Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science. - Characterizes oxidative stress within the framework of redox biology, redox signaling, and medicine - Empowers researchers and students to quantify specific reactants noninvasively, identify redox biomarkers, and advance translational studies - Features contributions from international leaders in oxidative stress and redox biology research |
| impact factor redox biology: Radicals for Life Ernst van Faassen, Anatoly Vanin, 2011-10-13 Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans. Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers. Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included. - First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes - Extensive bibliographic references, written by specialists of human physiology - Providing high scientific quality with a focus on implications for human diseases |
| impact factor redox biology: Redox Biochemistry Ruma Banerjee, 2007-12-04 This is the premier, single-source reference on redox biochemistry, a rapidly emerging field. This reference presents the basic principles and includes detailed chapters focusing on various aspects of five primary areas of redox biochemistry: antioxidant molecules and redox cofactors; antioxidant enzymes; redox regulation of physiological processes; pathological processes related to redox; and specialized methods. This is a go-to resource for professionals in pharmaceuticals, medicine, immunology, nutrition, and environmental fields and an excellent text for upper-level students. |
| impact factor redox biology: Cellular Implications Of Redox Signaling Avihai Danon, Carlos Gitler, 2003-07-30 Redox regulation, like phosphorylation, is a covalent regulatory system that controls many of the normal cellular functions of all living cells and organisms. In addition, it controls how cells respond to stress involving oxidants and free radicals, which underlie many degenerative diseases. This area is undergoing a transition from general knowledge to specific description of the components and mechanisms involved.This invaluable book provides a timely basic description of a field whose relevance to cell biology and degenerative diseases is of the utmost importance. It describes the state of the art, lays the foundations for understanding the reactions involved, and presents the prospects for future developments. It can serve as a basic text for any undergraduate or graduate course that deals with redox regulation, oxidative stress and free radicals under normal and pathological conditions in bacterial, plant and animal cells. |
| impact factor redox biology: Cell Biology by the Numbers Ron Milo, Rob Phillips, 2015-12-07 A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid |
| impact factor redox biology: Morphogenesis Jonathan B. L. Bard, Jonathan Bard, 1992-07-02 This book, first published in 1990, provides an overview of the events and mechanisms of morphogenesis. |
| impact factor redox biology: Oxidants and Antioxidants Lester Packer, 1999 General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * Total Antioxidant Activity * Vitamin C * Polyphenols and Flavanoids * Thiols * Vitamin E and Coenzyme Q10 * Carotenoids and Retinoids. |
| impact factor redox biology: How Tobacco Smoke Causes Disease United States. Public Health Service. Office of the Surgeon General, 2010 This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products. |
| impact factor redox biology: Antioxidants in Sport Nutrition Manfred Lamprecht, 2014-09-17 The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance. |
| impact factor redox biology: Women in plant science - redox biology of plant abiotic stress 2022 Laura De Gara, María C. Romero-Puertas, Christine Helen Foyer, Sabine Lüthje, Ana Zabalza, 2023-08-03 |
| impact factor redox biology: Insights in Aging, Metabolism and Redox Biology: 2021/2022 Jianhua Zhang , Changhan David Lee, 2024-07-08 We are now in the third decade of the 21st Century and, especially in recent years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Aging, Metabolism, and Redox Biology. This editorial initiative of particular relevance is focused on new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of Aging, Metabolism, and Redox Biology. |
| impact factor redox biology: Antioxidant and Redox Regulation of Genes Chandan K. Sen, Lester Packer, Patrick A. Baeuerle, 1999-11-08 This volume addresses oxidant-reduction or redox and antioxidant sensitive molecular mechanisms and how they are implicated in different disease processes. Possible strategies to pharmacologically and/or nutritionally manipulate such redox-sensitive molecular responses are emphasized. - Reactive species as intracellular messengers - Redox regulation of cellular responses - Clinical implications of redox signaling and antioxidant therapy |
| impact factor redox biology: Platelets in Cardiovascular Disease Deepak L. Bhatt, 2008 Platelets in Cardiovascular Disease provides an in-depth and current coverage of relevant platelet biology and antiplatelet therapy that is in clinical use today and potentially for the future. The book provides a succinct overview of the critical role of platelets in cardiovascular medicine. Cardiovascular disease is the leading cause of mortality worldwide, and recent research has found that the platelet is central to the genesis of heart attacks and stroke as well as many of the complications of angioplasty and bypass surgery. An explosion of knowledge of the biology of platelets has established their important role in the formation of blood clots and, perhaps more intriguingly, their role as inflammatory cells. This growth in information has been paralleled by the development of several drugs that can interfere with platelet action and thereby improve patient outcomes. Indeed, several antiplatelet drugs already in development may ultimately lead to marked advances in both the treatment and prevention of cardiovascular disease. Drawing upon a panel of international experts, Platelets in Cardiovascular Disease delivers a concise yet thorough review of the major developments in antiplatelet therapy. Practicing clinicians as well as those involved in the development of new antithrombotic therapies will find the book interesting and useful. Sample Chapter(s). Chapter 1: Platelet Biology the Role of Platelets in Hemostasis, Thrombosis and Inflammation (274 KB). Contents: Platelet Biology: The Role of Platelets in Hemostasis, Thrombosis and Inflammation (R C Becker); Thromboxane Antagonists (B R Dulin & S R Steinhubl); Glycoprotein IIb/IIIa Inhibitors (S J Lehman et al.); ADP Receptor Antagonists (J Karha & C P Cannon); Monitoring Antiplatelet Therapy (P Harrison & A D Michelson); Platelet Genomics (B K Jefferson et al.); Future Strategies for the Development of Antiplatelet Drugs (R A Harrington). Readership: Physicians: cardiologists, vascular medicine specialists, hematologists; physicians in training: fellows, residents, interns; pharmacists; pharmaceutical industry: scientists, sales representatives. |
| impact factor redox biology: Redox Chemistry and Biology of Thiols Beatriz Alvarez, Marcelo Comini, Gustavo Salinas, Madia Trujillo, 2022-05-25 Redox Chemistry and Biology of Thiols offers an applied, comprehensive overview of redox chemistry and biology of thiol-dependent processes. Running from basic biology and chemistry of redox phenomena to research methods and highlighting recently identified roles of thiols across cellular and bodily systems, this book draws upon a range of disciplines to illuminate new research directions, new applications of thiol studies, and clinical translation. Sections cover thiol oxidizing species, thiol reactivity and modifications, thioredoxin, glutaredoxin, glutathione, peroxidases, thiol repair enzymes, thiol oxidative signaling, disulfide bond formation, thiol-based redox biosensors, cysteine and hydrogen sulfide metabolism, iron-sulfur cluster biogenesis, thiols in chloroplasts, blood thiols, sugar and polyamine thiols in pathogenic organisms, redox medicine (therapeutic applications of thiols and drug development), as well as methods and bioinformatics tools. - Runs from basic thiol biology and chemistry to applications and clinical translation - Provides methods and protocols that will power new research across biomedicine, cell biology, plant biology, drug development, and protein folding and modulation - Includes chapter contributions from international leaders in the field |
| impact factor redox biology: Oxidative Stress and Antioxidant Protection Donald Armstrong, Robert D. Stratton, 2016-04-11 Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields. |
| impact factor redox biology: Redox Mohammed Awad Ali Khalid, 2017-09-06 Redox reactions are central to the major element cycling, many cell cycles, many chemisorption and physisorption processes, trace element mobility from rocks and sediments toward wells, aquifers, trace element toxicity toward life forms, and most remediation schemes including water treatments; over the last three decades, the field has attracted a lot of scientists, and a great deal of researches has been done in redox chemistry. This book provides a very broad overview of the state of the art of understanding redox processes, which starts with giving a concise introduction that describes the origin, historical background, and the development of the redox definitions. The book is organized into two sections that include ten chapters and introduces, in Section 1, generalized electron balance theory and its applications in electrolytic redox systems, redox-active molecules and its applications in device memory, fundamentals and applications of flow batteries and their integration into antidirect current, and donor acceptor titrations of displacement and electronic transference. Section 2 introduces redox in biological processes, including roles of reactive oxygen species in respiration, metabolism, and regulations, and redox in physiological processes as redox-sensitive TRP channels TRPA1 and TRPM2. All chapters are written by different authors (with the exception of Chapter 1 [Introduction]). This clearly reflects the broad range of topics that have been covered by experts in the field. |
| impact factor redox biology: Lipid Oxidation Amy S. Logan, Uwe Nienaber, Xiangqing (Shawn) Pan, 2015-08-15 Lipid oxidation in food systems is one of the most important factors which affect food quality, nutrition, safety, color and consumers' acceptance. The control of lipid oxidation remains an ongoing challenge as most foods constitute very complex matrices. Lipids are mostly incorporated as emulsions, and chemical reactions occur at various interfaces throughout the food matrix. Recently, incorporation of healthy lipids into food systems to deliver the desired nutrients is becoming more popular in the food industry. Many food ingredients contain a vast array of components, many of them unknown or constituting diverse or undefined molecular structures making the need in the food industry to develop effective approaches to mitigate lipid oxidation in food systems. This book provides recent perspectives aimed at a better understanding of lipid oxidation mechanisms and strategies to improve the oxidative stability of food systems. - Five chapters on naturally-derived antioxidants that focus on applications within food systems - Contributors include an international group of leading researchers from academic, industrial, and governmental entities - Discusses the oxidative stability of enzymatically produced oils and fats - Provides overviews on the complexities of lipid oxidation mechanisms, and emulsion systems most suseptible to rapid lipid oxidation |
| impact factor redox biology: Biotechnological Advances for Microbiology, Molecular Biology, and Nanotechnology Jyoti Ranjan Rout, Rout George Kerry, Abinash Dutta, 2022 Biotechnological Advances for Microbiology, Molecular Biology, and Nanotechnology: An Interdisciplinary Approach to the Life Sciences presents cutting-edge research associated with the beneficial implications of biotechnology on human welfare. The volume mainly focuses on the highly demanding thrust areas of biotechnology that are microbiology, molecular biology, and nanotechnology. The book provides a detailed overview of the beneficial roles of microbes and nanotechnology-based engineered particles in biological developments. Also, it highlights the role of epigenetic machinery and redox modulators during the development of diseases. In addition, it provides research on nanotechnology-based applications in tissue engineering, stem cell, and regenerative medicines. Overall, the book provides an extended platform for acquiring the methodological knowledge needed for today's biotechnological applications, such as DNA methylation, redox homeostasis, CRISPR, nano-based drug delivery systems, proteomics, genomics, metagenomics, bioluminescence, bioreactors, bioremediation, biosensors, etc. Divided into three sections, the book first highlights some recent trends in applied microbiology used in different areas, such as crop improvement, wastewater treatment, drug delivery, healthcare management, and more. The volume goes on to cover some advances in cellular and molecular mechanisms, such as CRISPR technology in biological systems, induced stem cells in disease prevention, integrated omics technology, and others. The volume also explores the indispensable role of nanotechnology in the precisely modulating intricate functioning of an organism in diagnostic and therapy along its application in tissue engineering and regenerative medicine and in food science as well as its role in ecological sustainability. This multidisciplinary volume will be highly valuable for the researchers, scientists, biologists, and faculty and students striving to expand their horizon of knowledge in their respective fields-- |
| impact factor redox biology: Zinc Signaling Toshiyuki Fukada, Taiho Kambe, 2019-12-13 This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students. |
| impact factor redox biology: The Role of Iron in Cancer Progression Maryam Mehrpour, Ahmed Hamaï, Chang Gong, 2022-11-04 |
| impact factor redox biology: The Rate of Living Raymond Pearl, 1928 |
| impact factor redox biology: Cartilage: From Biology to Biofabrication Mohamadreza Baghaban Eslaminejad, Samaneh Hosseini, 2023-07-11 This book provides a comprehensive overview of cartilage structure, functions, and approaches for the regeneration of cartilage tissue. It reviews multiple signaling pathways that are involved in the growth and repair of cartilage tissue. The initial chapter of the book examines the etiology, diagnosis, and pathological features of various cartilage diseases. Subsequently, the book presents recent advances in biomaterial sciences, regenerative medicine, and fabrication technology for cartilage regeneration. It discusses hydrogels as a promising scaffold for cartilage tissue engineering, focusing on recapitulating microenvironments present during development or in adult tissue to induce the formation of cartilaginous constructs with biochemical and mechanical properties of native tissue. Lastly, it covers the applications of 3 D printing techniques for the fabrication of scaffolds for cartilage tissue regeneration for the production of biological implants capable of treating a range of conditions. |
| impact factor redox biology: Redox and Metabolic Circuits in Cancer Salvatore Rizza, Andrea Rasola, Danyelle M. Townsend, Giuseppe Filomeni, 2018-12-21 Living cells require a constant supply of energy for the orchestration of a variety of biological processes in fluctuating environmental conditions. In heterotrophic organisms, energy mainly derives from the oxidation of carbohydrates and lipids, whose chemical bonds breakdown allows electrons to generate ATP and to provide reducing equivalents needed to restore the antioxidant systems and prevent from damage induced by reactive oxygen and nitric oxide (NO)-derived species (ROS and RNS). Studies of the last two decades have highlighted that cancer cells reprogram the metabolic circuitries in order to sustain their high growth rate, invade other tissues, and escape death. Therefore, this broad metabolic reorganization is mandatory for neoplastic growth, allowing the generation of adequate amounts of ATP and metabolites, as well as the optimization of redox homeostasis in the changeable environmental conditions of the tumor mass. Among these, ROS, as well as NO and RNS, which are produced at high extent in the tumor microenvironment or intracellularly, have been demonstrated acting as positive modulators of cell growth and frequently associated with malignant phenotype. Metabolic changes are also emerging as primary drivers of neoplastic onset and growth, and alterations of mitochondrial metabolism and homeostasis are emerging as pivotal in driving tumorigenesis. Targeting the metabolic rewiring, as well as affecting the balance between production and scavenging of ROS and NO-derived species, which underpin cancer growth, opens the possibility of finding selective and effective anti-neoplastic approaches, and new compounds affecting metabolic and/or redox adaptation of cancer cells are emerging as promising chemotherapeutic tools. In this Research Topic we have elaborated on all these aspects and provided our contribution to this increasingly growing field of research with new results, opinions and general overviews about the extraordinary plasticity of cancer cells to change metabolism and redox homeostasis in order to overcome the adverse conditions and sustain their “individualistic” behavior under a teleonomic viewpoint. |
| impact factor redox biology: Programmed Cell Death 2.0: The Quality of Cell Death Michael Thomas Lotze, Yinan Gong, Jennifer Martinez, Na Dong, 2022-02-14 |
| impact factor redox biology: Molecular Biology of the Cell , 2002 |
| impact factor redox biology: Biochemistry of Oxidative Stress Ricardo Jorge Gelpi, Alberto Boveris, Juan José Poderoso, 2016-12-28 The strongest point of this book titled “Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects”, is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects, to clinical application, including the antioxidant therapy. Of particular importance is the fact that the aforementioned aspects are described in the book in a general section and in three different and important pathologies, such as cardiovascular diseases, neurodegenerative diseases, and cancer. The importance of these pathologies lays in the fact that, taken separately or together, they represent by far the leading cause of death in the world. Finally, all the chapters have been written by highly recognized authorities in the field of their investigations. At least to our knowledge, this is the first book with this characteristics in the field of oxidative stress. |
| impact factor redox biology: Molecular Chaperones in Human Disorders , 2019-01-09 Molecular Chaperones in Human Disorders, Volume 114 in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair and their involvement in maintaining chromatin repair, the balance between chromosomal repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Chapters in this new release cover Functional principles and regulation of molecular chaperones, Chaperones and retinal disorders, Protein misfolding and degradation in genetic diseases, Chaperone dysfunction in hereditary myopathic diseases, Diseases caused by functional disorder of molecular chaperones residing in the endoplasmic reticulum, and many other timely topics. - Describes advances in our understanding on DNA repair mechanisms and the involvement of their dysregulation in promoting diseases - Provides an ideal resource for a very wide audience of specialists, researchers and students - Contains timely chapters written by well-renown authorities in their field - Presents information that is well supported by a number of high quality illustrations, figures and tables |
| impact factor redox biology: Redox Cell Biology and Genetics Chandan K. Sen, Lester Packer, 2002 |
| impact factor redox biology: Fermentation Processes Angela Jozala, 2017-02-08 Fermentation is a theme widely useful for food, feed and biofuel production. Indeed each of these areas, food industry, animal nutrition and energy production, has considerable presence in the global market. Fermentation process also has relevant applications on medical and pharmaceutical areas, such as antibiotics production. The present book, Fermentation Processes, reflects that wide value of fermentation in related areas. It holds a total of 14 chapters over diverse areas of fermentation research. |
| impact factor redox biology: Comprehensive Clinical Plasma Medicine Hans-Robert Metelmann, Thomas von Woedtke, Klaus-Dieter Weltmann, 2018-05-04 This book presents the state of the art in clinical plasma medicine and outlines translational research strategies. Written by an international group of authors, it is divided into four parts. Part I is a detailed introduction and includes basic and recent research information on plasma sciences, plasma devices and mechanisms of biological plasma effects. Parts II and III provide valuable clinical insights f.e. into the treatment of superficial contaminations, ulcerations, wounds, treatment of cells in cancer, special indications like in heart surgery, dentistry, palliative treatment in head and neck cancer or the use of plasma in hygiene. Part IV offers information on how and where to qualify in plasma medicine and which companies produce and supply medical devices and is thus of particular interest to medical practitioners. This comprehensive book offers a sciences based practical to the clinical use of plasma and includes an extended selection of scientific medical data and translational literature. |
| impact factor redox biology: Stress Response and Immunity: Links and Trade Offs Nadia Danilova, 2020-02-04 When environmental conditions deviate from the optimal range, stress ensues. Stress response is a set of reactions that allow the organism to adjust and survive adverse conditions. Stress can be physical, such as extreme temperature, radiation, injury, or psychological, caused by perceived danger or deprivation. Every living cell has biochemical mechanisms to cope with physical stress. These mechanisms show a degree of similarity among several types of living organisms. Stress Response and Immunity: Links and Trade Offs explores the functional and evolutionary connections between stress response and immunity. The book introduces the reader to the concept of stress and subsequently examines the connection between stress response and immunity at various evolutionary stages of living organisms - from bacteria to humans. The book also features chapters dedicated to the role of tumor suppressor genes and the immune system of the brain. The information presented in this reference demonstrates the profound effects of physical and psychological stress on human health. Readers with basic knowledge of molecular biology will learn about the interesting facets of stress responses and the evolutionary trade offs observed in different life forms. |
| impact factor redox biology: Oxidative Stress and Redox Regulation Ursula Jakob, Dana Reichmann, 2013-03-15 Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease. |
| impact factor redox biology: Active Oxygen in Chemistry Christopher S. Foote, Joan Selverstone Valentine, A. Greenberg, Joel F. Liebman, 2012-12-06 Taking an interdisciplinary approach, this book and its counterpart, Active Oxygen in Biochemistry, explore the active research area of the chemistry and biochemistry of oxygen. Complementary but independent, the two volumes integrate subject areas including medicine, biology, chemistry, engineering, and environmental studies. |
| impact factor redox biology: Redox-Active Therapeutics Ines Batinić-Haberle, Júlio S. Rebouças, Ivan Spasojević, 2016-10-13 This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). It encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and most notably metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome—the organism redox network—as an emerging frontier in drug design, redox biology and medicine. |
| impact factor redox biology: Oxidative Stress and Signal Transduction H.J. Forman, Enrique Cadenas, 2012-12-06 In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene. |
| impact factor redox biology: Reactive Oxygen Species (ROS) in Living Cells Filip Cristiana, Albu Elena, 2018-05-23 Oxygen represents only 20% of the Earth's atmosphere, yet it is vital for the survival of aerobic organisms. There is a dark part of the use of oxygen that consists in generating reactive species that are potentially harmful to living organisms. Moreover, reactive oxygen species can combine with nitrogen derivatives and generate many other reactive species. Thus, living organisms are continuously assaulted by reactive species from external or internal sources. However, the real danger comes in the case of high concentrations and prolonged exposure to these species. This book presents an image of the mechanisms of action of reactive species and emphasizes their involvement in diseases. Inflammation and cancer are examined to determine when and how reactive species turn the evolution of a benign process to a malignant one. Some answers may come from recent studies indicating that reactive species are responsible for epigenetic changes. |
| impact factor redox biology: The Routledge Handbook on Biochemistry of Exercise Peter M. Tiidus, Rebecca E. K. MacPherson, Paul J. LeBlanc, Andrea R. Josse, 2020-12-27 Very comprehensive and well-organized Handbook covering fundamental acute and chronic aspects of exercise and training, plus nutrition and ergogenic aids, and application to disease. Incorporates much of the new research that has been generated over the past decade, which has yet to be presented in a text book. The presented chapters comprehensively cover all aspects of exercise biochemistry Brings together an international and exceptional editorial team and contributing authors |
| impact factor redox biology: Toxicology Vinood B. Patel, Victor R Preedy, 2020-11-17 Toxicology: Oxidative Stress and Dietary Antioxidants examines the nature of oxidative stress as a consequence of exposure to toxins and how antioxidant approaches can mitigate the impact of toxicant exposures. Sections covers the basic biology of oxidative stress, from molecular biology, to physiological pathology, mechanisms of action of specific toxicants, metals and other chemicals/drugs, and antioxidant approaches and therapies for toxic exposures. With contributions from an international group of experts, useful summary sections, a dictionary of terms, and applications to other areas of toxicology, this book is an informative, consolidated reference that helps bridge the interrelationship between toxicology, oxidative stress and antioxidants. - Provides a novel collection of information linking both sides of redox biology (oxidants and antioxidants) and toxicology - Explores the role of free radical mediated damage and toxicology - Contains contributions from experts on toxicological science surrounding oxidative stress and on antioxidant approaches for reducing the impact of toxicant exposures |
