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Delving Deep into the Journal of Leukocyte Biology: A Comprehensive Guide
Introduction:
Are you a researcher, student, or simply fascinated by the complex world of leukocytes – the white blood cells crucial to our immune system? Understanding the latest advancements in leukocyte biology requires access to top-tier research, and that's where the Journal of Leukocyte Biology (JLB) comes in. This comprehensive guide will explore the significance of the JLB, its impact on the field, how to navigate its content, and what makes it an indispensable resource for anyone working within immunology, hematology, or related fields. We'll dissect its core areas of focus, discuss its publishing process, and provide you with the tools to effectively utilize this vital journal in your research endeavors.
Understanding the Journal of Leukocyte Biology (JLB)
The Journal of Leukocyte Biology stands as a leading peer-reviewed scientific journal dedicated to publishing high-impact research on all aspects of leukocyte biology. It's not just a collection of articles; it's a dynamic platform that fosters dialogue and drives advancements in our understanding of the immune system's intricate workings. From the molecular mechanisms governing leukocyte function to their roles in health and disease, the JLB covers a vast spectrum of research topics.
Key Areas of Focus within the Journal of Leukocyte Biology:
Leukocyte Development and Differentiation: The JLB extensively covers research investigating the complex processes involved in the formation and maturation of various leukocyte subtypes, including neutrophils, lymphocytes, monocytes, and others. This includes studies on hematopoietic stem cells, lineage commitment, and the regulatory pathways controlling these processes.
Leukocyte Signaling and Activation: Understanding how leukocytes respond to stimuli is crucial. The journal publishes research on intracellular signaling pathways, receptor activation, and the molecular mechanisms that orchestrate leukocyte activation, migration, and effector functions. This includes exploring the role of various cytokines, chemokines, and other signaling molecules.
Leukocyte Trafficking and Migration: Leukocytes are not static; they constantly patrol the body, migrating to sites of infection or injury. The JLB publishes research illuminating the mechanisms that guide this precise movement, including the roles of adhesion molecules, chemotaxis, and the extracellular matrix.
Leukocyte Effector Functions: Once activated, leukocytes execute critical effector functions, such as phagocytosis (engulfing pathogens), cytokine production, and cytotoxic activity. The JLB explores the molecular mechanisms underpinning these functions and how they contribute to immune responses.
Leukocytes in Health and Disease: A significant portion of the JLB's content focuses on the roles of leukocytes in various diseases, including infectious diseases, autoimmune disorders, cancer, and inflammatory conditions. Research explores how leukocyte dysfunction contributes to these pathologies and potential therapeutic targets.
Innovative Research Methodologies: The JLB embraces technological advancements, publishing studies utilizing cutting-edge techniques like advanced microscopy, flow cytometry, genomics, proteomics, and bioinformatics. These advancements allow for a deeper understanding of leukocyte biology at multiple levels.
Navigating the Journal of Leukocyte Biology: Tips for Researchers
Effectively utilizing the JLB requires a strategic approach:
Keyword Searches: Utilize the journal's advanced search function to pinpoint relevant articles based on keywords related to your specific research interest. Combine keywords for greater specificity.
Citation Tracking: If you've found a relevant article, use the citation tracking feature to identify other studies that have cited it, potentially leading you to related research you may have missed.
Author Tracking: Follow researchers whose work aligns with your interests. Many researchers maintain consistent publication patterns within the JLB.
Thematic Collections: The JLB often publishes thematic collections of articles focusing on specific areas of leukocyte biology. These provide a concentrated source of information on emerging topics.
Alert Services: Sign up for email alerts to receive notifications of newly published articles matching your specific search criteria. This ensures you're up-to-date on the latest research.
The Impact of the Journal of Leukocyte Biology
The JLB significantly contributes to the advancement of leukocyte biology by:
Disseminating Cutting-Edge Research: The journal serves as a primary vehicle for disseminating groundbreaking research to the scientific community.
Fostering Collaboration: It provides a platform for researchers to share their findings, sparking collaboration and knowledge exchange.
Shaping Future Research Directions: By highlighting key findings and emerging trends, the JLB helps shape the future direction of research in the field.
Informing Clinical Practice: The knowledge generated through JLB publications often translates into improvements in diagnostics and treatment strategies for various diseases.
Sample Journal Article Outline: "The Role of Neutrophils in Inflammatory Bowel Disease"
I. Introduction:
Background on inflammatory bowel disease (IBD) and its pathogenesis.
Overview of neutrophil function and its relevance to inflammation.
Research question and hypotheses.
II. Materials and Methods:
Description of study design (e.g., animal model, human samples).
Detailed explanation of experimental procedures.
Statistical analysis methods used.
III. Results:
Presentation of key findings, using tables and figures.
Statistical analysis of the data.
IV. Discussion:
Interpretation of results in relation to the hypotheses.
Comparison with existing literature.
Implications for future research and clinical practice.
V. Conclusion:
Summary of the main findings and their significance.
Limitations of the study.
Future research directions.
Detailed Explanation of the Sample Article Outline Points:
I. Introduction: This section provides the necessary background information, establishes the context of the research, and clearly states the research question and the hypotheses being tested. It sets the stage for the reader and highlights the significance of the work.
II. Materials and Methods: This crucial section provides a detailed and meticulous description of the experimental procedures, allowing other researchers to replicate the study. Transparency is paramount here. The inclusion of statistical analysis methods ensures the rigor of the research.
III. Results: This section presents the key findings of the research in a clear and concise manner, usually supported by tables and figures. The results should be presented objectively, without interpretation.
IV. Discussion: This section is where the researchers interpret the results in the context of the research question and hypotheses. It involves comparing the findings with existing literature, highlighting any inconsistencies or contradictions, and discussing the implications of the work.
V. Conclusion: This section summarizes the key findings and their broader significance. It also addresses any limitations of the study and suggests directions for future research.
Frequently Asked Questions (FAQs)
1. How can I access articles from the Journal of Leukocyte Biology? Many articles are available through institutional subscriptions or online databases like PubMed.
2. Is the JLB open access? Some articles may be open access, while others require subscriptions. Check the individual article for access information.
3. What types of articles are published in the JLB? The JLB publishes original research articles, reviews, and occasional editorials.
4. How is research submitted to the JLB? The submission process is typically online via the journal's website, and it involves a rigorous peer-review process.
5. What are the impact factors of the JLB? Impact factors vary and are best checked on resources like Journal Citation Reports.
6. Who is the target audience of the JLB? Researchers, students, and clinicians in the fields of immunology, hematology, and related disciplines.
7. What is the publication frequency of the JLB? The publication frequency is typically monthly or bimonthly.
8. Can I submit a letter to the editor to the JLB? Yes, many journals accept letters to the editor to discuss published articles or current issues in the field. Check the JLB's guidelines.
9. How long does the peer-review process typically take for the JLB? The duration varies, but it generally involves several months.
Related Articles:
1. The Role of Macrophages in Immune Response: Explores the diverse functions of macrophages in innate and adaptive immunity.
2. Lymphocyte Development and Maturation: A detailed examination of the different stages and signaling pathways involved in lymphocyte development.
3. Neutrophil Extracellular Traps (NETs) in Infection: Discusses the role of NETs in trapping and killing pathogens.
4. Dendritic Cells and Antigen Presentation: A deep dive into the role of dendritic cells in initiating adaptive immune responses.
5. NK Cells and Cancer Immunotherapy: Focuses on the role of natural killer cells in anti-tumor immunity and their use in cancer therapies.
6. Monocyte Subsets and Their Functions: Examines the various subsets of monocytes and their specialized roles in inflammation and immune regulation.
7. Eosinophils and Allergic Diseases: Explores the role of eosinophils in allergic inflammation and their contribution to allergic diseases.
8. Basophils and Mast Cells in Immune Response: Discusses the roles of basophils and mast cells in allergic reactions and other immune responses.
9. Leukocyte Signaling Pathways in Inflammation: A detailed analysis of the signaling pathways that govern leukocyte activation and function during inflammation.
| journal of leukocyte: Leukocyte Typing II Ellis L. Reinherz, Barton F. Haynes, Lee M. Nadler, Irwin D. Bernstein, 2012-12-06 The Second International Workshop on Human Leukocyte Differentia- tion Antigens was held in Boston, September 17-20, 1984. More than 350 people interested in leukocyte differentiation agreed to exchange reagents and participate in this joint venture. All in all, in excess of 400 antibodies directed against surface structures on T lymphocytes, B lymphocytes, and myeloid-hematopoietic stem cells were characterized. Because of the enormous quantity of serologic, biochemical, and functional data, Leuko- cyte Typing II has been divided into three volumes. These books represent the written results of workshop participants. They should be helpful to both researchers and clinicians involved in scientific endeavors dealing with these broad fields of immunobiology. To those who delve into the various sections of the volumes, it will become evident that the work speaks for itself. I am deeply indebted to the section editors, Barton F. Haynes, Volume 1, Human T Lymphocytes, Lee M. Nadler, Volume 2, Human B Lympho- cytes, and Irwin D.Bernstein, Volume 3, Human Myeloid and Hemato- poietic Cells for their major contributions in planning, executing, and summarizing the workshop, as well as council members John Hansen, Alain Bernard, Laurence Boumsell, Walter Knapp, Andrew McMichael, Cesar Milstein, and Stuart F. Schlossman. I would also like to thank the National Institutes of Health, World Health Organization, and Interna- tional Union of Immunological Societies for making this meeting possible. |
| journal of leukocyte: Mast Cells and Basophils Gianni Marone, Lawrence M. Lichtenstein, Federica J. Galli, 2000-05-25 Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists. |
| journal of leukocyte: Molecular Biology of the Cell , 2002 |
| journal of leukocyte: The Impact of Food Bioactives on Health Kitty Verhoeckx, Paul Cotter, Iván López-Expósito, Charlotte Kleiveland, Tor Lea, Alan Mackie, Teresa Requena, Dominika Swiatecka, Harry Wichers, 2015-04-29 “Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena. |
| journal of leukocyte: Mononuclear Phagocytes Ralph van Furth, 1975 |
| journal of leukocyte: Leukocyte Trafficking Alf Hamann, Britta Engelhardt, 2006-05-12 Written by known specialists in the field, this is a comprehensive and timely overview of a central and expanding topic. Simultaneously an introduction and a description of the latest concepts, findings and methods, the handbook provides basic knowledge on technical issues required for those intending to research in the field. It covers the functional role of involved molecules and the cellular mechanisms, and addresses selected examples for their possible application in therapy -- bridging the gap between trafficking mechanisms and novel therapeutic strategies. In addition, it includes selection of proven and timesaving methods for studying cell trafficking in vitro and in vivo. The accompanying CD-ROM makes leukocyte migration videos available to a broad audience for the first time. |
| journal of leukocyte: Inflammation and the Microcirculation D. Neil Granger, Elena Senchenkova, 2010 The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References |
| journal of leukocyte: Endothelial Cell Dysfunctions M. Simionescu, N. Simionescu, 2013-11-11 Noted experts survey and evaluate the latest research in the growing field of endothelial cell involvement in the initiation and development of various diseases. Research-oriented chapters span a diversity of topics, including endothelial cell response to various injuries and its crucial role in inflammation, immunity, viral infection, hypertension, hyperlipidemia, atherosclerosis, diabetes mellitus, neoplasia, and metastasis. |
| journal of leukocyte: The Leucocyte Antigen Factsbook A. Neil Barclay, Marion H. Brown, S. K. Alex K. Alex Law, Andrew J. McKnight, Michael G. Tomlinson, P. Anton van der Merwe, 1997-06-22 A volume in the popular FactsBook Series, the First Edition of The Leucocyte Antigen FactsBook was hugely successful. The new Second Edition has been completely revised, updated, and expanded by 65% to include new findings and up-to-date key references. The introductory chapters have also been updated, especially in terms of nomenclature, the role of the World Wide Web, and new structural data. The Leucocyte Antigen FactsBook, Second Edition contains more than 200 entries, with approximately 70 new entries, on all the molecules specifically expressed in the surface of cells of the haematopoietic system, including all characterized CD antigens, antigen receptors, MHC antigens, adhesion molecules, and cytokine receptors. This FactsBook will be of enormous value to immunologists, cell biologists, biochemists, and endocrinologists.Key Features* Completely up-to-date* Revised and expanded to include over 70 new entries* More than 200 entries in total, plus additional introductory material* New structural data* New nomenclature for CD and related molecules covered |
| journal of leukocyte: Interpretation of Equine Laboratory Diagnostics Nicola Pusterla, Jill Higgins, 2017-12-18 Interpretation of Equine Laboratory Diagnostics offers a comprehensive approach to equine laboratory diagnostics, including hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics. Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to establish and new diagnostic procedures Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to established and new diagnostic procedures |
| journal of leukocyte: Vasculitis Gene V. Ball, S. Louis Bridges, 2008 This is a new edition of the successful textbook providing updated, detailed information on clinical, epidemiologic, pathophysiologic and therapeutic aspects of common and rare forms of vasculitis. New chapters include pathology of vasculitis, autoantibodies, animal models of vasculitis and PET scanning. Separate sections are devoted to basic science, clinical manifestations commonly seen in vasculitis, imaging and perpcutaneous interventions, individual diseases and syndromes as well as conditions which can mimic vasculitis. Subsumed under clinical manifestations are chapters, some new, which deal with skin, oral ulcers, eyes, cardiopulmonary system, nervous system, the gastrointestinal track, kidney and digital ischemia and Raynaud's phenomenon. Other chapters address diagnostic approaches to adults and to children with suspected vasculitis, as well as assessment of disease activity and damage. Individual chapters are written by authorities from throughout the world. |
| journal of leukocyte: Inflammation, 4 Volume Set Jean-Marc Cavaillon, Mervyn Singer, 2018-02-20 Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten. |
| journal of leukocyte: Cooperation of Liver Cells in Health and Disease Z. Kmiec, 2013-06-29 It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions. |
| journal of leukocyte: The Peroxidase Multigene Family of Enzymes Petro E. Petrides, William M. Nauseef, 2000-08-04 In September 1998 experts from 19 countries came together for an interdisciplinary discussion of the function of animal peroxidases, a family of enzymes embracing myeloperoxidase, eosinophil peroxidase, thyroid peroxidase and lactoperoxidase. Their papers have been updated for publication, yielding a wide-ranging overview of the state of the art. The chapters cover a wide range of topics, including three-dimensional structure of representative family members, their biosynthesis and intracellular transport, mechanism of action as well as applications to clinical medicine. They are of clinical relevance in, for example, arteriosclerosis, multiple sclerosis, infections, tumorigenesis, rheumatic diseases and hypothyroidism. This book forms an excellent introduction for anyone interested in the peroxidase family of enzymes. |
| journal of leukocyte: The Biogeography of Host-Parasite Interactions Serge Morand, Boris R. Krasnov, 2010-07 This edited volume demonstrates how the latest developments in biogeography (for example in phylogenetics, macroecology, and geographic information systems) can be applied to studies in the evolutionary ecology of host-parasite interactions in order to integrate spatial patterns with ecological theory. |
| journal of leukocyte: Targeting Leukocyte Trafficking: Insights and Future Directions Helen Michelle McGettrick, Sian M. Henson, Vicky L. Morrison, Ronen Sumagin, 2022-02-04 |
| journal of leukocyte: Journal of the National Cancer Institute , 1981 |
| journal of leukocyte: The Immune Response Tak W. Mak, Mary E. Saunders, 2005-11-11 The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. - Current and thorough 30 chapter reference reviewed by luminaries in the field - Unique 'single voice' ensures consistency of definitions and concepts - Comprehensive and elegant illustrations bring key concepts to life - Provides historical context to allow fuller understanding of key issues - Introductory chapters 1-4 serve as an 'Immunology Primer' before topics are discussed in more detail |
| journal of leukocyte: Janeway's Immunobiology Kenneth Murphy, Paul Travers, Mark Walport, Peter Walter, 2010-06-22 The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes. |
| journal of leukocyte: The HLA Complex in Biology and Medicine Narinder K Mehra, 2010-11-26 A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics. |
| journal of leukocyte: Imaging and Mechanism of Leukocyte Recruitment and Function in Inflammation and Infections Zhichao Fan, Yuqing Huo, Hao Sun, Xunbin Wei, 2021-07-05 |
| journal of leukocyte: The White Cell Martin J. Cline, 1975 This is the only comprehensive and critical account, in a single volume, of the leukocytes. It cuts across scientific and clinical disciplines to provide a unified review of granulocytes, monocytes, and lymphocytes, both as individual cell types and as they form an integrated system of defense against the body's foreign invaders. Sections on each cell type discuss first normal and then abnormal aspects of morphogenesis and morphology, the kinetics of production, distribution, life span, metabolism and function. Specific disease states are reviewed in the context of pathophysiological mechanisms. Readable, and beautifully illustrated with photomicrographs, electron micrographs, diagrams and drawings, this book will serve a broad audience of physicians and scientists as well as students seeking a basic grounding in the field. More than 6,000 references are cited; the reader will find a perspective on the historical development of leukocyte biology as well as a current summary of a rapidly changing field. Not only hematologists, but workers in the basic disciplines of immunology and cell biology, and in the clinical fields of oncology, genetics, infectious disease, surgery, and related areas, will turn to this book as the fundamental teaching and reference work on white cells. |
| journal of leukocyte: Clinical Benefits of Leukodepleted Blood Products Joseph Sweeney, 2013-06-29 Joseph Sweeney, Andrew Heaton he presence of allogeneic leukocytes in blood products received little T attention until the mid-1950s when these passenger cells were im plicated in the etiology of febrile transfusion reactions, and early strate gies based on centrifugation were developed to effect their removal. In recent decades and, particularly in the past five years, there has been an accumulation of literature implicating leukocytes in a wide variety of undesirable reactions to blood transfusion. White cells are the least numerous of the cellular elements in blood and ratios of white cells to platelets and white cells to red cells are ap proximately 1:15 to 1:1000 respectively. This ratio is maintained in whole blood, but may be altered slightly in the process of component prepara tion. Any production or processing step which intentionally decreases this ratio will result in a product which can be described as white cell depleted. It has, however, become more common to define the outcome as a residual white cell content, rather than a decrease in cellular ratios, although the latter makes more sense on theoretical grounds, since deple tion of white cells needs to be put in the context of any unintentional loss of red cells or platelets. The end result of this intentional processing step, therefore, is generally expressed as the residual absolute number of white cells or as the degree of difference in white cell content, the latter expressed as either a percentage change or as a logarithmic reduction. |
| journal of leukocyte: Laboratory Hematology Practice Kandice Kottke-Marchant, Bruce Davis, 2012-05-07 Expertly edited and endorsed by the International Society for Laboratory Hematology, this is the newest international textbook on all aspects of laboratory hematology. Covering both traditional and cutting-edge hematology laboratory technology this book emphasizes international recommendations for testing practices. Illustrative case studies on how technology can be used in patient diagnosis are included. Laboratory Hematology Practice is an invaluable resource for all those working in the field. |
| journal of leukocyte: Stem Cells in Animal Species: From Pre-clinic to Biodiversity Tiziana A.L. Brevini, 2014-08-29 This volume focuses on stem cell research and disease modeling in non-murine species. The book is divided into three parts: Stem Cells for Pre-Clinical Models, Stem Cells in Non-Conventional Species, and Stem Cell Banking for the Future. The first section presents an overview of the different pre-clinical stem cell models recently created in animal species, including the porcine model for heart failure, iPSC in large animal species, Duchenne muscular dystrophy and canine embryo-derived stem cells and modeling for human diseases. This section also discusses the potential advantages and applications of these models. The second part of this book describes recent efforts to use stem cells for preserving endangered species, including the snow leopard and coral reefs. From this perspective, stem cells are an invaluable tool to preserve bio-diversities. Frozen cells and gametes can be obtained from animals at risk of extinction and even from microorganisms and corals suffering from heavy changes in the eco-system; this may allow the cultivation of a generation of stem cell lines and represents an exciting opportunity to support and ensure the conservation of precious varieties of living creatures. This discussion leads easily into the third section, which discusses stem cell banking as a way of safeguarding these endangered species. |
| journal of leukocyte: Handbook of Lithium Therapy F.N. Johnson, 2012-12-06 As a medical student in the 1930s, I remember well that a very clear line of distinction was drawn between physical illness and mental illness. Physical illness resulted from pathology which could be identified and studied in detail and the cause could often be deduced. Treatment thus was often specific and based upon a proper appreciation of underlying basic science. Mental illness, on the other hand, could not, it was believed, be based upon identifiable changes in basic science. It was literally 'all in the mind' and, occurring in the absence of causes that could be identified, analysed and remedied, had no treatment that could in any way be called specific. N ow it is all too easy, in Medicine, for a doctor to become so immersed in a specialty that he fails to notice how his colleagues in other specialties are faring and, through laziness, to miss advances even of fundamental importance in fields other than those in which he himself works. As a consultant surgeon, after W orId War II, although I realized the importance of keeping in touch with those medical specialties which appeared to have a common interface with my own surgical interests, such as general medi cine, gastro-enterology, hepatology and endocrinology, it did not occur to me that there was any pressing need to ask what was new in Psychological Medicine. |
| journal of leukocyte: Rheumatology and Immunology Therapy Larry W. Moreland, 2004-07-20 Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field |
| journal of leukocyte: Laboratory Diagnosis of Urinary Tract Infections Jill E. Clarridge, James R. Johnson, Marie T. Pezzlo, 1998 |
| journal of leukocyte: HLA in Health and Disease Robert Lechler, Anthony Warrens, 2000-05-09 This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in 1994. This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference. The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system. It clarifies its complex and ever changing nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity. It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine, haematology, molecular biology and biochemistry. Key Features Structure, function and genetics of HLA HLA nomenclature Evolution of HLA polymorphisms HLA associations in arthritis and rheumatology, renal disease, neurology, diabetes and endocrinology, gastroenterology, respiratory disease, ophthalmology, infections, dermatology and psychiatry HLA and organ transplantation Serological and PCR-based methods in HLA typing Cellular techniques in testing histocompatibility Edited and written by an international panel of experts in the field |
| journal of leukocyte: Periodical Title and Abbreviation by Abbreviation Leland G. Alkire, Cheryl Westerman-Alkire, 2006 Volume 1 is a comprehensive dictionary with more than 230,000 entries. It covers periodicals from a wide variety of subjects, including: science, social sciences, humanities, law, medicine, religion, library science, engineering, education, business, and art. Volume 1lists, in a single in letter-by-letter sequence, abbreviations commonly used for periodicals together with their full titles. |
| journal of leukocyte: Cell Biology of Trauma John J. Lemasters, Constance Oliver, 2020-08-16 This unique book presents an approach to viewing trauma. It examines the cellular consequences of trauma at a molecular level and provides new insights into the treatment of traumatic injury, based on cellular responses. The current of trauma research is reviewed, previously unpublished information on the topic is presented, and research directions are included. |
| journal of leukocyte: Biochemistry of Inflammation J. Whicher, S.W. Evans, 2012-12-06 Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification and cloning. This book brings together ideas from a number of different biochemical disciplines which are frequently not integrated. The first chapter gives a visual overview of the subject; the remaining chapters are organized into three themes: the affector molecules, the regulatory components and the processes of inflammation itself. This book is essential reading for the busy physician or pathologist who wants to be up-to-date with the latest developments in immunology as they affect the diagnosis and treatment of many conditions. |
| journal of leukocyte: Cumulated Index Medicus , 1984 |
| journal of leukocyte: Feigin and Cherry's Textbook of Pediatric Infectious Diseases E-Book James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, Peter J Hotez, 2013-10-05 Feigin and Cherry's Textbook of Pediatric Infectious Diseases helps you put the very latest knowledge to work for your young patients with unparalleled coverage of everything from epidemiology, public health, and preventive medicine through clinical manifestations, diagnosis, treatment, and much more. Ideal for all physicians, whether in an office or hospital setting, Feigin and Cherry’s equips you with trusted answers to your most challenging clinical infectious disease questions. Meet your most difficult clinical challenges in pediatric infectious disease, including today’s more aggressive infectious and resistant strains as well as emerging and re-emerging diseases, with unmatched, comprehensive coverage of immunology, epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. Find the answers you need quickly thanks to an organization both by organ system and by etiologic microorganism, allowing you to easily approach any topic from either direction. |
| journal of leukocyte: Handbook on Immunosenescence Tamas Fulop, Claudio Franceschi, Katsuiki Hirokawa, Graham Pawelec, 2009-02-27 This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more. |
| journal of leukocyte: Macrophages and Related Cells Michael A. Horton, 2013-06-29 To produce a comprehensive overview of macrophages and related cell types in a short review volume is an impossible task. When I selected the topics to be included, some equally important areas were omitted by necessity, and for this I apologize. My choices have been somewhat eclectic, touching subjects of personal interest (such as osteoclast biology and macrophage electrophysiology) or of current fashion (apopto sis, antigen processing, cell adhesion molecules). The book has also had to encompass areas of a more general flavor to provide balance for the general reader (such as reviews of macrophage development, heterogeneity, and function, and of the surface molecules expressed by macrophages). I thank all the authors for their prompt sub missions; all have been of high quality, and my editorial tasks, thankfully, have been minimal. Michael A. Horton London, United Kingdom ix Contents Chapter J An Overview of Receptors of MPS Cells lain Fraser and Siam on Gordon 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. The Mononuclear Phagocyte System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3. Diversity of Macrophage Plasma Membrane Receptors. . . . . . . . . . . . . . . . 6 3. 1 A Structural Approach to Classification . . . . . . . . . . . . . . . . . . . . . . . . . . 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 2 Multisubunit Receptors 3. 3 Soluble Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 4 Lectins and Lectin-Like Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Functions and Selected Examples. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 1 Growth, Differentiation, and Modulation . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 2 Cell-Cell and Cell-Matrix Interactions. . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 3 Endocytosis and Scavenger Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 4 Secretory Responses and Biosynthesis of Effector Molecules . . . . . . 17 5. Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 6. References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 . . . . . . . . . . . . . . . . . . . . |
| journal of leukocyte: Pulmonary Immunotoxicology Mitchell D. Cohen, Judith T. Zelikoff, Richard B. Schlesinger, 2012-12-06 Pulmonary Immunotoxicology is a comprehensive exploration of the effects of various inhaled materials upon the immune system of the respiratory tract. It will be useful to investigators in the field of pulmonary toxicology and immunotoxicology, and to those involved in administration and regulation of matters related to inhaled materials. It can also serve as a textbook for a course in pulmonary immunotoxicology at graduate or advanced undergraduate level. Pulmonary Immunotoxicology comprises four sections. The first provides basic background concepts essential for understanding pulmonary immunotoxicology, including discussions of the normal structure and function of the respiratory system, its basic immunology, and the manner by which inhaled particles and gases are removed from the air and deposited upon respiratory tract surfaces. The second section provides an overview of the major types of pathological consequences which can arise from immunomodulation within the respiratory tract, including hypersensitivity and asthma, inflammation and fibrosis, as well as immunosuppression and autoimmunity. The third section, which comprises the largest portion of the book, deals specifically with major classes of airborne agents that are known to alter the immune function of the respiratory tract. These are arranged into major classes: organic agents, metals, gases, particles, biologics, and complex mixtures. The fourth and final section of the book explores the area of risk assessment, including discussions of the basic concepts of risk assessment as they apply specifically to immunotoxicologic effects upon the lungs, and the use of biomarkers as indices of potential pulmonary immunotoxic responses to inhaled materials. |
| journal of leukocyte: The Philadelphia Medical Journal , 1898 |
| journal of leukocyte: Surface and Interfacial Aspects of Cell Adhesion Alain Carre, Kash L. Mittal, 2011-01-19 Cell adhesion comes into play in almost all domains of life. The range of situations in which it occurs, involving organisms, living tissues, microorganisms or single cells, is endless. Cell adhesion is involved in the binding of a cell to a surface, extracellular matrix, or another cell using cell adhesion molecules. It is crucial in the formation |
| journal of leukocyte: The Philadelphia Medical Journal George Milbry Gould, James Hendrie Lloyd, 1898 |
