Mouse Genetics Gizmo

Decoding the Mysteries: A Deep Dive into Mouse Genetics Gizmo

Introduction:

Have you ever wondered about the intricate world of genetics, hidden within the seemingly simple creature – the mouse? For researchers, the humble mouse is a powerhouse of genetic information, offering invaluable insights into human health and disease. This comprehensive guide delves into the fascinating realm of "Mouse Genetics Gizmo," a term encompassing the vast array of tools and techniques used to study mouse genetics, from gene editing technologies like CRISPR-Cas9 to sophisticated bioinformatics analyses. We'll explore the significance of mouse models in biomedical research, discuss cutting-edge techniques, and examine the ethical considerations involved. Get ready to unravel the secrets behind this powerful gizmo in the quest for scientific breakthroughs!


1. The Mouse: A Model Organism of Unparalleled Importance

The house mouse (Mus musculus) has become the gold standard in mammalian genetics research. Its relatively short lifespan, ease of breeding, and remarkably similar genetic makeup to humans make it an ideal model for studying a wide range of biological processes, including:

Disease Modeling: Mice can be genetically engineered to develop human diseases, providing researchers with valuable tools to study disease mechanisms and test potential therapies. Conditions such as cancer, Alzheimer's disease, and diabetes are commonly modeled in mice.
Developmental Biology: Mouse embryos offer a clear window into the complex processes of embryonic development, helping scientists understand how organs form and how genetic mutations can lead to birth defects.
Gene Function: By manipulating genes in mice, researchers can investigate the role of specific genes in various biological processes, gaining crucial insights into gene function and regulation.
Pharmacology and Toxicology: Mice are widely used to test the efficacy and safety of new drugs and chemicals, providing crucial data before human clinical trials.


2. Key Tools in the Mouse Genetics Gizmo Toolbox

The "gizmo" of mouse genetics encompasses a wide range of sophisticated techniques:

Gene Targeting: This involves precisely modifying or deleting genes in mice to study their function. Techniques like homologous recombination and CRISPR-Cas9 are frequently employed.
Transgenic Mice: These mice carry extra copies of a specific gene, allowing researchers to study the effects of gene overexpression.
Knockout Mice: In these mice, a specific gene has been completely disabled, allowing researchers to analyze the consequences of gene loss.
Knockin Mice: Here, a specific gene is replaced with a modified version, often incorporating a fluorescent tag or a disease-causing mutation.
Conditional Knockout Mice: These mice allow for gene deletion in specific tissues or at specific developmental stages, offering greater control and precision.
CRISPR-Cas9 Gene Editing: This revolutionary technology allows for highly precise and efficient gene editing, enabling the creation of sophisticated mouse models with unprecedented speed and accuracy.
Next-Generation Sequencing (NGS): NGS technologies allow for rapid and cost-effective sequencing of entire genomes, providing a comprehensive view of genetic variations in mouse models.


3. Bioinformatics and Data Analysis: Making Sense of the Mouse Genome

The sheer volume of data generated from mouse genetic studies requires sophisticated bioinformatics tools for analysis. These tools are essential for:

Genome Assembly: Assembling the fragmented DNA sequences obtained from NGS into a complete genome.
Gene Annotation: Identifying genes, regulatory elements, and other functional features within the genome.
Variant Calling: Identifying genetic variations, such as single nucleotide polymorphisms (SNPs) and insertions/deletions (indels).
Gene Expression Analysis: Analyzing gene expression levels across different tissues or conditions using techniques like RNA sequencing (RNA-Seq).
Pathway Analysis: Identifying biological pathways that are affected by genetic variations or environmental factors.


4. Ethical Considerations in Mouse Genetics Research

The use of mice in research raises important ethical considerations. It is crucial to:

Minimize animal suffering: Researchers must adhere to strict guidelines to ensure the humane treatment of animals, minimizing pain and distress.
Justify the use of animals: Research proposals must undergo rigorous ethical review to ensure that the potential benefits of the research outweigh the potential harms to the animals.
Use the 3Rs: The 3Rs (Replacement, Reduction, Refinement) are guiding principles aimed at minimizing the use of animals in research.


5. Future Directions in Mouse Genetics Research

The field of mouse genetics is constantly evolving, with ongoing advancements in:

Gene editing technologies: Further refinements in CRISPR-Cas9 and other gene editing technologies promise even greater precision and efficiency.
High-throughput screening: High-throughput technologies are enabling researchers to screen vast libraries of compounds for therapeutic potential.
Humanized mouse models: These models incorporate human cells or tissues, offering improved models for human diseases.
Organoids: Three-dimensional cultures of human cells are providing valuable alternatives to animal models in certain contexts.



Article Outline: Decoding the Mysteries: A Deep Dive into Mouse Genetics Gizmo

I. Introduction: Hook, overview of the post's contents.
II. The Mouse: A Model Organism: Discusses the advantages of using mice in research.
III. Key Tools in the Mouse Genetics Gizmo Toolbox: Details various techniques used in mouse genetics.
IV. Bioinformatics and Data Analysis: Explains the importance of bioinformatics in analyzing mouse genomic data.
V. Ethical Considerations: Addresses ethical concerns related to animal research.
VI. Future Directions: Discusses emerging trends and future advancements.
VII. Conclusion: Summarizes key takeaways and emphasizes the importance of mouse genetics research.


(Detailed explanation of each point is provided above in the article itself.)


FAQs:

1. What are the limitations of using mice as models for human diseases? While mice share many genetic similarities with humans, there are also significant differences that can affect the translatability of research findings.
2. How is CRISPR-Cas9 used in mouse genetics? CRISPR-Cas9 allows for precise gene editing in mice, enabling the creation of knockouts, knockins, and other sophisticated models.
3. What are the ethical implications of creating genetically modified mice? Ethical considerations include minimizing animal suffering, justifying the use of animals, and adhering to the 3Rs (Replacement, Reduction, Refinement).
4. What role does bioinformatics play in mouse genetics research? Bioinformatics is crucial for analyzing the massive datasets generated by genomic studies, enabling researchers to interpret the data and draw meaningful conclusions.
5. What are some alternative models to mice in research? Alternatives include in vitro cell cultures, zebrafish, Drosophila, and other model organisms.
6. How are transgenic mice created? Transgenic mice are created by introducing foreign DNA into their genome, often using techniques such as pronuclear injection.
7. What is a conditional knockout mouse? A conditional knockout mouse allows for gene deletion in specific tissues or at specific developmental stages, providing greater control over gene manipulation.
8. What is the cost associated with mouse genetics research? The cost can vary significantly depending on the specific techniques used, the scale of the research, and the facilities involved.
9. Where can I find more information on mouse genetics research? Numerous resources are available online, including scientific journals, databases, and research institutions dedicated to mouse genetics.


Related Articles:

1. CRISPR-Cas9: Revolutionizing Gene Editing in Mice: Discusses the application of CRISPR-Cas9 in mouse genetics.
2. The Power of Knockout Mice in Biomedical Research: Explores the uses of knockout mice in studying gene function.
3. Transgenic Mice: A Powerful Tool for Studying Gene Overexpression: Explores the creation and application of transgenic mice.
4. Ethical Considerations in Animal Research: A Focus on Mouse Models: Details the ethical considerations involved in using mice in research.
5. Bioinformatics Tools for Analyzing Mouse Genomic Data: Explains various bioinformatics tools used in mouse genomics.
6. Next-Generation Sequencing (NGS) in Mouse Genetics: Discusses the application of NGS in analyzing mouse genomes.
7. Mouse Models of Human Diseases: A Comprehensive Overview: Provides a detailed overview of mouse models used for various human diseases.
8. Conditional Gene Knockout: Enhancing Precision in Mouse Genetics: Focuses on conditional knockout mice and their advantages.
9. The Future of Mouse Genetics: Emerging Technologies and Applications: Looks ahead at future trends in mouse genetics research.


  mouse genetics gizmo: Using Technology with Classroom Instruction that Works Howard Pitler, Elizabeth Ross Hubbell, Matt Kuhn, 2012 Learn how to improve instruction by * Collecting the right data--the right way. * Incorporating relevant data into everyone's daily life. * Resisting the impulse to set brand-new goals every year. * Never settling for good enough. * Anticipating changes--big and small, local and federal. * Collaborating and avoiding privatized practice. * Involving all stakeholders in identifying problems, setting goals, and analyzing data. * Agreeing on what constitutes high-quality instruction and feedback. The challenge is to understand that data--not intuition or anecdotal reports--are tools to be used in getting better at teaching students. And teaching students effectively is what schools are all about. Following the guidance in this book, overcome uncertainty and concerns about data as you learn to collect and analyze both soft and hard data and use their secrets for instructional improvement in your school.
  mouse genetics gizmo: Science Units for Grades 9-12 Randy L. Bell, Joe Garofalo, 2005 Sample topics include cell division, virtual dissection, earthquake modeling, the Doppler Effect, and more!
  mouse genetics gizmo: Technology in the Secondary Science Classroom Randy L. Bell, Julie Gess-Newsome, Julie Luft, 2008 If you're waiting to be convinced that computers offer more than pricey bells and whistles in the classroom, this is the book that will open your mind to technology's potential. But even if you're an early (and avid) adopter, you'll discover intriguing new concepts for technology-based teaching strategies that help students really learn science concepts. The featured technologies range from the easy to master (such as digital cameras) to the more complex (such as Probeware and geographic information systems). Among the chapter topics: digital images and video for teaching science; using computer simulations; Probeware tools for science investigations; extending inquiry with geo-technologies; acquiring online data for scientific analysis; Web-based inquiry products, and online assessments and hearing students think about science. The book's emphasis is never on technology for technology's sake. Each chapter includes a summary of current research on the technology's effectiveness in the classroom; best-practice guidelines drawn from the research and practitioner literature; and innovative ideas for teaching with the particular technology. The goal is to stimulate your thinking about using these tools, and deepen your students' engagement in science content.
  mouse genetics gizmo: Using Technology with Classroom Instruction That Works Howard Pitler, Elizabeth R. Hubbell, Matt Kuhn, 2012-08-02 Technology is ubiquitous, and its potential to transform learning is immense. The first edition of Using Technology with Classroom Instruction That Works answered some vital questions about 21st century teaching and learning: What are the best ways to incorporate technology into the curriculum? What kinds of technology will best support particular learning tasks and objectives? How does a teacher ensure that technology use will enhance instruction rather than distract from it? This revised and updated second edition of that best-selling book provides fresh answers to these critical questions, taking into account the enormous technological advances that have occurred since the first edition was published, including the proliferation of social networks, mobile devices, and web-based multimedia tools. It also builds on the up-to-date research and instructional planning framework featured in the new edition of Classroom Instruction That Works, outlining the most appropriate technology applications and resources for all nine categories of effective instructional strategies: * Setting objectives and providing feedback * Reinforcing effort and providing recognition * Cooperative learning * Cues, questions, and advance organizers * Nonlinguistic representations * Summarizing and note taking * Assigning homework and providing practice * Identifying similarities and differences * Generating and testing hypotheses Each strategy-focused chapter features examples—across grade levels and subject areas, and drawn from real-life lesson plans and projects—of teachers integrating relevant technology in the classroom in ways that are engaging and inspiring to students. The authors also recommend dozens of word processing applications, spreadsheet generators, educational games, data collection tools, and online resources that can help make lessons more fun, more challenging, and—most of all—more effective.
  mouse genetics gizmo: Mouse Genetics Lee M. Silver, 1995
  mouse genetics gizmo: Mouse Genetics Professor of Molecular Biology Lee M Silver, Professor Dr, Lee M. Silver, 1995 Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interpreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.
  mouse genetics gizmo: Tomorrow Now Bruce Sterling, 2003 Predicting that the next generation will be living in a substantially different world, a forecast for the next fifty years discusses such topics as technology, health, law enforcement, and politics, and has been updated to include an all-new afterword. Reprint. 15,000 first printing.
  mouse genetics gizmo: Mouse Genetics Shree Ram Singh, Robert M. Hoffman, Amit Singh, 2021 This fully updated edition provides selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages, and modeling human diseases. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mouse Genetics: Methods and Protocols, Second Edition delivers fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students, and postdoctoral fellows working in the various disciplines of genetics, developmental biology, mouse genetics, and modeling human diseases.
  mouse genetics gizmo: Human Genome News , 1989
  mouse genetics gizmo: The Best Care Possible Ira Byock, 2012-03-15 A palliative care doctor on the front lines of hospital care illuminates one of the most important and controversial ethical issues of our time on his quest to transform care through the end of life. It is harder to die in this country than ever before. Statistics show that the vast majority of Americans would prefer to die at home, yet many of us spend our last days fearful and in pain in a healthcare system ruled by high-tech procedures and a philosophy to fight disease and illness at all cost. Dr. Ira Byock, one of the foremost palliative-care physicians in the country, argues that end-of-life care is among the biggest national crises facing us today. In addressing the crisis, politics has trumped reason. Dr. Byock explains that to ensure the best possible care for those we love-and eventually ourselves- we must not only remake our healthcare system, we must also move past our cultural aversion to talking about death and acknowledge the fact of mortality once and for all. Dr. Byock describes what palliative care really is, and-with a doctor's compassion and insight-puts a human face on the issues by telling richly moving, heart-wrenching, and uplifting stories of real people during the most difficult moments in their lives. Byock takes us inside his busy, cutting-edge academic medical center to show what the best care at the end of life can look like and how doctors and nurses can profoundly shape the way families experience loss. Like books by Atul Gawande and Jerome Groopman, The Best Care Possible is a compelling meditation on medicine and ethics told through page-turning, life or death medical drama. It is passionate and timely, and it has the power to lead a new kind of national conversation.
  mouse genetics gizmo: Water and Biomolecules Kunihiro Kuwajima, Yuji Goto, Fumio Hirata, Masahide Terazima, Mikio Kataoka, 2009-03-18 Life is produced by the interplay of water and biomolecules. This book deals with the physicochemical aspects of such life phenomena produced by water and biomolecules, and addresses topics including Protein Dynamics and Functions, Protein and DNA Folding, and Protein Amyloidosis. All sections have been written by internationally recognized front-line researchers. The idea for this book was born at the 5th International Symposium Water and Biomolecules, held in Nara city, Japan, in 2008.
  mouse genetics gizmo: Thinking in Java Bruce Eckel, 2003 Provides link to sites where book in zip file can be downloaded.
  mouse genetics gizmo: Mouse Genetics and Transgenics Ian J. Jackson, Cathy Abbott, 1999-12-09 A unique book that integrates knowledge from a wide range of expertise, specifically applied to the mouse, and addressed at a wide audience from those new to the field to experts who want an update on the state of the art. Mouse Genetics and Transgenics: APA covers all aspects of using the mouse as a genetic model organism: care & husbandry; archiving stocks as frozen embryos or sperm; making new mutations by chemical mutagenesis; transgenesis; and gene targetting; mapping mutations and polygenic traits by cytogenetic, genetic, and physical means; and disseminating and researching information via the Internet.
  mouse genetics gizmo: Information Arts Stephen Wilson, 2003-02-28 An introduction to the work and ideas of artists who use—and even influence—science and technology. A new breed of contemporary artist engages science and technology—not just to adopt the vocabulary and gizmos, but to explore and comment on the content, agendas, and possibilities. Indeed, proposes Stephen Wilson, the role of the artist is not only to interpret and to spread scientific knowledge, but to be an active partner in determining the direction of research. Years ago, C. P. Snow wrote about the two cultures of science and the humanities; these developments may finally help to change the outlook of those who view science and technology as separate from the general culture. In this rich compendium, Wilson offers the first comprehensive survey of international artists who incorporate concepts and research from mathematics, the physical sciences, biology, kinetics, telecommunications, and experimental digital systems such as artificial intelligence and ubiquitous computing. In addition to visual documentation and statements by the artists, Wilson examines relevant art-theoretical writings and explores emerging scientific and technological research likely to be culturally significant in the future. He also provides lists of resources including organizations, publications, conferences, museums, research centers, and Web sites.
  mouse genetics gizmo: I Am a Strange Loop Douglas R Hofstadter, 2007-08-01 One of our greatest philosophers and scientists of the mind asks, where does the self come from -- and how our selves can exist in the minds of others. Can thought arise out of matter? Can self, soul, consciousness, I arise out of mere matter? If it cannot, then how can you or I be here? I Am a Strange Loop argues that the key to understanding selves and consciousness is the strange loop-a special kind of abstract feedback loop inhabiting our brains. The most central and complex symbol in your brain is the one called I. The I is the nexus in our brain, one of many symbols seeming to have free will and to have gained the paradoxical ability to push particles around, rather than the reverse. How can a mysterious abstraction be real-or is our I merely a convenient fiction? Does an I exert genuine power over the particles in our brain, or is it helplessly pushed around by the laws of physics? These are the mysteries tackled in I Am a Strange Loop, Douglas Hofstadter's first book-length journey into philosophy since Gödel, Escher, Bach. Compulsively readable and endlessly thought-provoking, this is a moving and profound inquiry into the nature of mind.
  mouse genetics gizmo: Information Needs of Communities Steven Waldman, 2011-09 In 2009, a bipartisan Knight Commission found that while the broadband age is enabling an info. and commun. renaissance, local communities in particular are being unevenly served with critical info. about local issues. Soon after the Knight Commission delivered its findings, the FCC initiated a working group to identify crosscurrent and trend, and make recommendations on how the info. needs of communities can be met in a broadband world. This report by the FCC Working Group on the Info. Needs of Communities addresses the rapidly changing media landscape in a broadband age. Contents: Media Landscape; The Policy and Regulatory Landscape; Recommendations. Charts and tables. This is a print on demand report.
  mouse genetics gizmo: Maelstrom Peter Watts, 2009-01-06 Second in the Rifters Trilogy, Hugo Award-winning author Peter Watts' Maelstrom is a terrifying explosion of cyberpunk noir. This is the way the world ends: A nuclear strike on a deep sea vent. The target was an ancient microbe—voracious enough to drive the whole biosphere to extinction—and a handful of amphibious humans called rifters who'd inadvertently released it from three billion years of solitary confinement. The resulting tsunami killed millions. It's not as through there was a choice: saving the world excuses almost any degree of collateral damage. Unless, of course, you miss the target. Now North America's west coast lies in ruins. Millions of refugees rally around a mythical figure mysteriously risen from the deep sea. A world already wobbling towards collapse barely notices the spread of one more blight along its shores. And buried in the seething fast-forward jungle that use to be called Internet, something vast and inhuman reaches out to a woman with empty white eyes and machinery in her chest. A woman driven by rage, and incubating Armageddon. Her name is Lenie Clarke. She's a rifter. She's not nearly as dead as everyone thinks. And the whole damn world is collateral damage as far as she's concerned. . . . At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
  mouse genetics gizmo: The History of Our Tribe Barbara Welker, 2017-01-31 Where did we come from? What were our ancestors like? Why do we differ from other animals? How do scientists trace and construct our evolutionary history? The Evolution of Our Tribe: Hominini provides answers to these questions and more. The book explores the field of paleoanthropology past and present. Beginning over 65 million years ago, Welker traces the evolution of our species, the environments and selective forces that shaped our ancestors, their physical and cultural adaptations, and the people and places involved with their discovery and study. It is designed as a textbook for a course on Human Evolution but can also serve as an introductory text for relevant sections of courses in Biological or General Anthropology or general interest. It is both a comprehensive technical reference for relevant terms, theories, methods, and species and an overview of the people, places, and discoveries that have imbued paleoanthropology with such fascination, romance, and mystery.
  mouse genetics gizmo: The Mouse in Animal Genetics and Breeding Research Eugene J. Eisen, 2005 The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and genetics of disease resistance, and have been written by experts in their respective fields.Chapter 1: The Beginnings - Ode To A Wee Mouse (58 KB)
  mouse genetics gizmo: Exploring Digital Design Ina Wagner, Tone Bratteteig, Dagny Stuedahl, 2010-08-12 Exploring Digital Design takes a multi-disciplinary look at digital design research where digital design is embedded in a larger socio-cultural context. Working from socio-technical research areas such as Participatory Design (PD), Computer Supported Cooperative Work (CSCW) and Human-Computer Interaction (HCI), the book explores how humanities offer new insights into digital design, and discusses a variety of digital design research practices, methods, and theoretical approaches spanning established disciplinary borders. The aim of the book is to explore the diversity of contemporary digital design practices in which commonly shared aspects are interpreted and integrated into different disciplinary and interdisciplinary conversations. It is the conversations and explorations with humanities that further distinguish this book within digital design research. Illustrated with real examples from digital design research practices from a variety of research projects and from a broad range of contexts Exploring Digital Design offers a basis for understanding the disciplinary roots as well as the interdisciplinary dialogues in digital design research, providing theoretical, empirical, and methodological sources for understanding digital design research. The first half of the book Exploring Digital Design is authored as a multi-disciplinary approach to digital design research, and represents novel perspectives and analyses in this research. The contributors are Gunnar Liestøl, Andrew Morrison and Christina Mörtberg in addition to the editors. Although primarily written for researchers and graduate students, digital design practioners will also find the book useful. Overall, Exploring Digital Design provides an excellent introduction to, and resource for, research into digital design.
  mouse genetics gizmo: The Future of Technology Tom Standage, 2005-08-01 From the industrial revolution to the railway age, through the era of electrification, the advent of mass production, and finally to the information age, the same pattern keeps repeating itself. An exciting, vibrant phase of innovation and financial speculation is followed by a crash, after which begins a longer, more stately period during which the technology is actually deployed properly. This collection of surveys and articles from The Economist examines how far technology has come and where it is heading. Part one looks at topics such as the “greying” (maturing) of IT, the growing importance of security, the rise of outsourcing, and the challenge of complexity, all of which have more to do with implementation than innovation. Part two looks at the shift from corporate computing towards consumer technology, whereby new technologies now appear first in consumer gadgets such as mobile phones. Topics covered will include the emergence of the mobile phone as the “digital Swiss Army knife”; the rise of digital cameras, which now outsell film-based ones; the growing size and importance of the games industry and its ever-closer links with other more traditional parts of the entertainment industry; and the social impact of technologies such as text messaging, Wi-Fi, and camera phones. Part three considers which technology will lead the next great phase of technological disruption and focuses on biotechnology, energy technology, and nanotechnology.
  mouse genetics gizmo: Makers Chris Anderson, 2012-10-02 3D Robotics co-founder and bestselling author Chris Anderson takes you to the front lines of a new industrial revolution as today’s entrepreneurs, using open source design and 3-D printing, bring manufacturing to the desktop. In an age of custom-fabricated, do-it-yourself product design and creation, the collective potential of a million garage tinkerers and enthusiasts is about to be unleashed, driving a resurgence of American manufacturing. A generation of “Makers” using the Web’s innovation model will help drive the next big wave in the global economy, as the new technologies of digital design and rapid prototyping gives everyone the power to invent--creating “the long tail of things”.
  mouse genetics gizmo: The Shallows Nicholas Carr, 2020-09-29 The 10th-anniversary edition of this landmark investigation into how the Internet is dramatically changing how we think, remember and interact, with a new afterword.
  mouse genetics gizmo: Why Zebras Don't Get Ulcers Robert M. Sapolsky, 2004-09-15 Renowned primatologist Robert Sapolsky offers a completely revised and updated edition of his most popular work, with over 225,000 copies in print Now in a third edition, Robert M. Sapolsky's acclaimed and successful Why Zebras Don't Get Ulcers features new chapters on how stress affects sleep and addiction, as well as new insights into anxiety and personality disorder and the impact of spirituality on managing stress. As Sapolsky explains, most of us do not lie awake at night worrying about whether we have leprosy or malaria. Instead, the diseases we fear-and the ones that plague us now-are illnesses brought on by the slow accumulation of damage, such as heart disease and cancer. When we worry or experience stress, our body turns on the same physiological responses that an animal's does, but we do not resolve conflict in the same way-through fighting or fleeing. Over time, this activation of a stress response makes us literally sick. Combining cutting-edge research with a healthy dose of good humor and practical advice, Why Zebras Don't Get Ulcers explains how prolonged stress causes or intensifies a range of physical and mental afflictions, including depression, ulcers, colitis, heart disease, and more. It also provides essential guidance to controlling our stress responses. This new edition promises to be the most comprehensive and engaging one yet.
  mouse genetics gizmo: Essential Statistics, Regression, and Econometrics Gary Smith, 2015-06-08 Essential Statistics, Regression, and Econometrics, Second Edition, is innovative in its focus on preparing students for regression/econometrics, and in its extended emphasis on statistical reasoning, real data, pitfalls in data analysis, and modeling issues. This book is uncommonly approachable and easy to use, with extensive word problems that emphasize intuition and understanding. Too many students mistakenly believe that statistics courses are too abstract, mathematical, and tedious to be useful or interesting. To demonstrate the power, elegance, and even beauty of statistical reasoning, this book provides hundreds of new and updated interesting and relevant examples, and discusses not only the uses but also the abuses of statistics. The examples are drawn from many areas to show that statistical reasoning is not an irrelevant abstraction, but an important part of everyday life. - Includes hundreds of updated and new, real-world examples to engage students in the meaning and impact of statistics - Focuses on essential information to enable students to develop their own statistical reasoning - Ideal for one-quarter or one-semester courses taught in economics, business, finance, politics, sociology, and psychology departments, as well as in law and medical schools - Accompanied by an ancillary website with an instructors solutions manual, student solutions manual and supplementing chapters
  mouse genetics gizmo: The Prokaryotes Martin Dworkin, Stanley Falkow, Eugene Rosenberg, Karl-Heinz Schleifer, Erko Stackebrandt, 2006-12-13 With the launch of its first electronic edition, The Prokaryotes, the definitive reference on the biology of bacteria, enters an exciting new era of information delivery. Subscription-based access is available. The electronic version begins with an online implementation of the content found in the printed reference work, The Prokaryotes, Second Edition. The content is being fully updated over a five-year period until the work is completely revised. Thereafter, material will be continuously added to reflect developments in bacteriology. This online version features information retrieval functions and multimedia components.
  mouse genetics gizmo: Medical Microbiology Illustrated S. H. Gillespie, 2014-06-28 Medical Microbiology Illustrated presents a detailed description of epidemiology, and the biology of micro-organisms. It discusses the pathogenicity and virulence of microbial agents. It addresses the intrinsic susceptibility or immunity to antimicrobial agents. Some of the topics covered in the book are the types of gram-positive cocci; diverse group of aerobic gram-positive bacilli; classification and clinical importance of erysipelothrix rhusiopathiae; pathogenesis of mycobacterial infection; classification of parasitic infections which manifest with fever; collection of blood for culture and control of substances hazardous to health. The classification and clinical importance of neisseriaceae is fully covered. The definition and pathogenicity of haemophilus are discussed in detail. The text describes in depth the classification and clinical importance of spiral bacteria. The isolation and identification of fungi are completely presented. A chapter is devoted to the laboratory and serological diagnosis of systemic fungal infections. The book can provide useful information to microbiologists, physicians, laboratory scientists, students, and researchers.
  mouse genetics gizmo: Cat Sense John Bradshaw, 2013-09-10 Cats have been popular household pets for thousands of years, and their numbers only continue to rise. Today there are three cats for every dog on the planet, and yet cats remain more mysterious, even to their most adoring owners. Unlike dogs, cats evolved as solitary hunters, and, while many have learned to live alongside humans and even feel affection for us, they still don’t quite “get us” the way dogs do, and perhaps they never will. But cats have rich emotional lives that we need to respect and understand if they are to thrive in our company. In Cat Sense, renowned anthrozoologist John Bradshaw takes us further into the mind of the domestic cat than ever before, using cutting-edge scientific research to dispel the myths and explain the true nature of our feline friends. Tracing the cat’s evolution from lone predator to domesticated companion, Bradshaw shows that although cats and humans have been living together for at least eight thousand years, cats remain independent, predatory, and wary of contact with their own kind, qualities that often clash with our modern lifestyles. Cats still have three out of four paws firmly planted in the wild, and within only a few generations can easily revert back to the independent way of life that was the exclusive preserve of their predecessors some 10,000 years ago. Cats are astonishingly flexible, and given the right environment they can adapt to a life of domesticity with their owners—but to continue do so, they will increasingly need our help. If we’re to live in harmony with our cats, Bradshaw explains, we first need to understand their inherited quirks: understanding their body language, keeping their environments—however small—sufficiently interesting, and becoming more proactive in managing both their natural hunting instincts and their relationships with other cats. A must-read for any cat lover, Cat Sense offers humane, penetrating insights about the domestic cat that challenge our most basic assumptions and promise to dramatically improve our pets’ lives—and ours.
  mouse genetics gizmo: Evil Genius Catherine Jinks, 2008-04-01 Cadel Piggott has a genius IQ and a fascination with systems of all kinds. At seven, he was illegally hacking into computers. Now he’s fourteen and studying for his World Domination degree, taking classes like embezzlement, forgery, and infiltration at the institute founded by criminal mastermind Dr. Phineas Darkkon. Although Cadel may be advanced beyond his years, at heart he’s a lonely kid. When he falls for the mysterious and brilliant Kay-Lee, he begins to question the moral implications of his studies. But is it too late to stop Dr. Darkkon from carrying out his evil plot? This ebook includes a sample chapter of GENIUS SQUAD.
  mouse genetics gizmo: Bold Peter H. Diamandis, Steven Kotler, 2016-02-23 Bold is a radical how-to guide for using exponential technologies, moonshot thinking, and crowd-powered tools to create extraordinary wealth while also positively impacting the lives of billions. A follow-up to the authors' Abundance (2012).
  mouse genetics gizmo: Business Law in Canada Richard Yates, 1998-06-15 Appropriate for one-semester courses in Administrative Law at both college and university levels. Legal concepts and Canadian business applications are introduced in a concise, one-semester format. The text is structured so that five chapters on contracts form the nucleus of the course, and the balance provides stand-alone sections that the instructor may choose to cover in any order. We've made the design more reader-friendly, using a visually-appealing four-colour format and enlivening the solid text with case snippets and extracts. The result is a book that maintains the strong legal content of previous editions while introducing more real-life examples of business law in practice.
  mouse genetics gizmo: Learning and Behavior Paul Chance, 2013-02-26 LEARNING AND BEHAVIOR, Seventh Edition, is stimulating and filled with high-interest queries and examples. Based on the theme that learning is a biological mechanism that aids survival, this book embraces a scientific approach to behavior but is written in clear, engaging, and easy-to-understand language.
  mouse genetics gizmo: Genetics of the Mouse Jean Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli, 2014-11-29 This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.
  mouse genetics gizmo: Essentials of Polymer Science and Engineering Paul C. Painter, Michael M. Coleman, 2009 Written by two of the best-known scientists in the field, Paul C. Painter and Michael M. Coleman, this unique text helps students, as well as professionals in industry, understand the science, and appreciate the history, of polymers. Composed in a witty and accessible style, the book presents a comprehensive account of polymer chemistry and related engineering concepts, highly illustrated with worked problems and hundreds of clearly explained formulas. In contrast to other books, 'Essentials' adds historical information about polymer science and scientists and shows how laboratory discoveries led to the development of modern plastics.--DEStech Publications web-site.
  mouse genetics gizmo: Fanged Noumena Nick Land, 2011-04-01 A dizzying trip through the mind(s) of the provocative and influential thinker Nick Land. During the 1990s British philosopher Nick Land's unique work, variously described as “rabid nihilism,” “mad black deleuzianism,” and “cybergothic,” developed perhaps the only rigorous and culturally-engaged escape route out of the malaise of “continental philosophy” —a route that was implacably blocked by the academy. However, Land's work has continued to exert an influence, both through the British “speculative realist” philosophers who studied with him, and through the many cultural producers—writers, artists, musicians, filmmakers—who have been invigorated by his uncompromising and abrasive philosophical vision. Beginning with Land's early radical rereadings of Heidegger, Nietzsche, Kant and Bataille, the volume collects together the papers, talks and articles of the mid-90s—long the subject of rumour and vague legend (including some work which has never previously appeared in print)—in which Land developed his futuristic theory-fiction of cybercapitalism gone amok; and ends with his enigmatic later writings in which Ballardian fictions, poetics, cryptography, anthropology, grammatology and the occult are smeared into unrecognisable hybrids. Fanged Noumena gives a dizzying perspective on the entire trajectory of this provocative and influential thinker's work, and has introduced his unique voice to a new generation of readers.
  mouse genetics gizmo: Evolution Education Re-considered Ute Harms, Michael J. Reiss, 2019-07-16 This collection presents research-based interventions using existing knowledge to produce new pedagogies to teach evolution to learners more successfully, whether in schools or elsewhere. ‘Success’ here is measured as cognitive gains, as acceptance of evolution or an increased desire to continue to learn about it. Aside from introductory and concluding chapters by the editors, each chapter consists of a research-based intervention intended to enable evolution to be taught successfully; all these interventions have been researched and evaluated by the chapters’ authors and the findings are presented along with discussions of the implications. The result is an important compendium of studies from around the word conducted both inside and outside of school. The volume is unique and provides an essential reference point and platform for future work for the foreseeable future.
  mouse genetics gizmo: Animation from Pencils to Pixels Tony White, 2012-09-10 Just add talent! Award-winning animator Tony White brings you the ultimate book for digital animation. Here you will find the classic knowledge of many legendary techniques revealed, paired with information relevant to today's capable, state-of-the-art technologies. White leaves nothing out. What contemporary digital animators most need to know can be found between this book's covers - from conceptions to creation and through the many stages of the production pipeline to distribution. This book is intended to serve as your one-stop how-to animation guide. Whether you're new to animation or a very experienced digital animator, here you'll find fundamentals, key classical techniques, and professional advice that will strengthen your work and well-roundedness as an animator. Speaking from experience, White presents time-honored secrets of professional animaton with a warm, masterly, and knowledgeable approach that has evolved from over 30 years as an award-winning animator/director. The book's enclosed downloadable resources presents classic moments from animation's history through White's personal homage to traditional drawn animation, Endangered Species. Using movie clips and still images from the film, White shares the 'making of' journal of the film, detailing each step, with scene-by-scene descriptions, technique by technique. Look for the repetitive stress disorder guide on the downloadable resources, called, Mega-hurts. Watch the many movie clips for insights into the versatility that a traditional, pencil-drawn approach to animaton can offer.
  mouse genetics gizmo: Roget's 21st Century Thesaurus in Dictionary Form Barbara Ann Kipfer, Princeton Language Institute, 1993 Combining scholarly authority with a new awareness of today's communication demands, Roget's 21st Century Thesaurus is the simple, reliable way to find the perfect word for your needs. It features as easy-to-use dictionary format plus a revolutionary concept index that arranges words by idea, thus enhancing the user's process of association, and leading scores of additional selections. The inclusion of a wide spectrum of words and phrases with each entry -- from sophisticated choices to completely new vocabulary in the language -- brings the user an exceptional number of alternatives to fit any variation of style and tone. Created by a leading expert in linguists and lexicography with today's communication needs in mind. More word choices than any other thesaurus -- Over 1 million words! Concise definitions for each main entry. A revolutionary concept index -- arranged by idea, it mirrors the way we actually think! No obsolete terms -- all synonyms reflect modern usage.
  mouse genetics gizmo: Visual Ergonomics Handbook Jeffrey Anshel, 2005-06-22 Viewing an electronic display screen varies significantly from reading text on paper and human eyes often suffer for it. Featuring cutting-edge research in the field of visual ergonomics, Visual Ergonomics Handbook focuses on vision and eye-care issues in both the office and industrial setting, including eye safety issues in industrial plants and c
  mouse genetics gizmo: Case Studies in Science Education: The case reports , 1978