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Decoding the Definition of Somatic in Biology: A Comprehensive Guide
Introduction:
Have you ever encountered the term "somatic" in a biology textbook or scientific article and felt a pang of confusion? You're not alone. While seemingly simple, the definition of "somatic" in biology encompasses a broad range of implications crucial to understanding biological processes, genetics, and even disease. This comprehensive guide will delve deep into the definition of somatic, exploring its various facets, its role in different biological contexts, and its significance in the wider field of life sciences. We’ll unravel the complexities, clarify common misconceptions, and provide you with a solid understanding you can confidently apply. Prepare to unlock the secrets of somatic cells and their profound influence on the living world.
What Does Somatic Mean in Biology? A Clear Definition
The word "somatic" originates from the Greek word "soma," meaning "body." In biology, somatic cells are any biological cells forming the body of a multicellular organism other than gametes, germ cells, gametocytes or undifferentiated stem cells. Simply put, they are the cells that make up all the tissues and organs of your body – your skin, muscles, bones, organs, and everything in between. These cells are diploid, meaning they contain two complete sets of chromosomes (one from each parent), unlike gametes (sperm and egg cells), which are haploid with only one set of chromosomes.
This seemingly straightforward definition opens the door to a fascinating exploration of somatic cell functions, their lifecycle, and their relevance to various biological phenomena.
Distinguishing Somatic Cells from Germ Cells: A Key Difference
The key distinction between somatic and germ cells lies in their reproductive roles. Somatic cells are involved in the day-to-day functions of the organism, contributing to growth, repair, and maintenance. They are not directly involved in sexual reproduction. In contrast, germ cells are the precursor cells to gametes, specifically designed for the transmission of genetic information to the next generation. This fundamental difference has profound implications for how mutations and genetic changes are inherited.
The Somatic Cell Cycle: Growth and Division
Somatic cells reproduce through a process called mitosis. Mitosis is a type of cell division that results in two daughter cells, each identical to the parent cell. This ensures genetic consistency across the organism. The somatic cell cycle, encompassing interphase (growth and DNA replication) and the mitotic phase (cell division), is meticulously regulated to prevent errors and maintain tissue integrity. Dysregulation of this cycle can lead to uncontrolled cell growth, a hallmark of cancer.
Somatic Mutations: Their Impact and Inheritance
Somatic mutations are alterations in the DNA sequence of somatic cells. These mutations occur after fertilization and are not inherited by offspring. While they may not affect future generations, they can significantly impact the individual carrying the mutation. Somatic mutations are a major driver of aging and age-related diseases, and they also play a crucial role in the development of cancer. For example, a somatic mutation in a skin cell could lead to skin cancer, but this mutation won't be passed on to the individual's children.
Somatic Cell Nuclear Transfer: Applications and Ethics
Somatic cell nuclear transfer (SCNT) is a laboratory technique used to create cloned animals. It involves transferring the nucleus of a somatic cell into an enucleated egg cell (an egg cell with its nucleus removed). This technique has been used to create cloned animals like Dolly the sheep, and it has important implications for research in areas such as regenerative medicine and disease modeling. However, SCNT raises significant ethical concerns regarding animal welfare and its potential misuse.
Somatic Gene Therapy: Targeting Somatic Cells for Treatment
Somatic gene therapy is a promising approach to treating genetic diseases. This technique involves modifying the genes in somatic cells to correct a genetic defect. Unlike germline gene therapy (which targets germ cells and would affect future generations), somatic gene therapy only affects the individual receiving the treatment. It's a powerful tool with the potential to cure or alleviate a variety of genetic disorders, but it’s also under ongoing development and research.
Conclusion: Understanding the Significance of Somatic Cells
The concept of "somatic" in biology, though seemingly simple, underpins a vast array of biological processes and has significant implications for health, disease, and biotechnology. From understanding cell division to exploring gene therapy and cloning, appreciating the definition of somatic cells is fundamental to comprehending the intricate workings of life. This exploration has hopefully clarified the nuances and significance of somatic cells, empowering you with a deeper understanding of this crucial biological concept.
Article Outline: "Definition of Somatic in Biology"
I. Introduction: Hooking the reader with a relatable scenario and outlining the article's scope.
II. Defining "Somatic" in Biology: A clear, concise definition with supporting examples.
III. Somatic vs. Germ Cells: Highlighting the key differences and their reproductive implications.
IV. The Somatic Cell Cycle: Describing mitosis and its regulation.
V. Somatic Mutations and Their Consequences: Exploring the impact of mutations on the individual.
VI. Somatic Cell Nuclear Transfer (SCNT): Discussing the technique, applications, and ethical considerations.
VII. Somatic Gene Therapy: A Powerful Therapeutic Tool: Explaining the method and its potential benefits.
VIII. Conclusion: Summarizing key takeaways and highlighting the broader significance of the topic.
IX. FAQs: Answering frequently asked questions.
FAQs:
1. What is the difference between somatic and germline mutations? Somatic mutations occur in somatic cells and are not inherited, while germline mutations occur in germ cells and are passed down to offspring.
2. Can somatic mutations be reversed? While not directly reversible, some therapies aim to mitigate their effects or prevent their progression.
3. Are all somatic cells identical? No, somatic cells differentiate into various specialized cell types with unique functions.
4. What role do somatic cells play in cancer development? Uncontrolled proliferation of somatic cells due to mutations is a hallmark of cancer.
5. What are the ethical concerns surrounding SCNT? Concerns include animal welfare, potential for human cloning, and the creation of genetically modified organisms.
6. How successful is somatic gene therapy? Success rates vary depending on the specific disease and the therapeutic approach. It's an ongoing area of research and development.
7. What are some examples of somatic cell types? Skin cells, muscle cells, nerve cells, and liver cells are all examples of somatic cells.
8. Can somatic cells become germ cells? Under specific experimental conditions, it may be possible, but it's not a naturally occurring process.
9. What is the significance of studying somatic cells? Understanding somatic cells is vital for comprehending development, aging, disease, and developing novel therapies.
Related Articles:
1. Mitosis vs. Meiosis: A detailed comparison of the two types of cell division.
2. The Cell Cycle and its Regulation: A comprehensive overview of the cell cycle checkpoints and control mechanisms.
3. Types of Cell Mutations and Their Effects: A thorough exploration of various mutations and their consequences.
4. Cancer Biology and Treatment Strategies: Focusing on the role of somatic mutations in cancer development and treatment options.
5. Regenerative Medicine and Cell Therapy: Exploring the potential of cell-based therapies to repair damaged tissues.
6. Ethical Considerations in Biotechnology: A discussion of ethical issues related to genetic engineering and cloning.
7. Human Genome Project and its Impact: An overview of the project's accomplishments and its implications for medicine.
8. Stem Cell Biology and Applications: Exploring the properties and applications of various stem cell types.
9. Genetic Diseases and Their Treatment: A discussion of inherited genetic disorders and potential treatment approaches, including gene therapy.
| definition of somatic in biology: Molecular Biology of the Cell , 2002 |
| definition of somatic in biology: Exploring the Biological Contributions to Human Health Institute of Medicine, Board on Health Sciences Policy, Committee on Understanding the Biology of Sex and Gender Differences, 2001-07-02 It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers. |
| definition of somatic in biology: Essentials of Stem Cell Biology Robert Lanza, John Gearhart, Brigid Hogan, Douglas Melton, Roger Pedersen, E. Donnall Thomas, James A. Thomson, Ian Wilmut, 2009-06-05 First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered. - Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries - Contributions by Nobel Laureates and leading international investigators - Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough - Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate - Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references |
| definition of somatic in biology: Scientific and Medical Aspects of Human Reproductive Cloning National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Policy and Global Affairs, Committee on Science, Engineering, and Public Policy, 2002-06-17 Human reproductive cloning is an assisted reproductive technology that would be carried out with the goal of creating a newborn genetically identical to another human being. It is currently the subject of much debate around the world, involving a variety of ethical, religious, societal, scientific, and medical issues. Scientific and Medical Aspects of Human Reproductive Cloning considers the scientific and medical sides of this issue, plus ethical issues that pertain to human-subjects research. Based on experience with reproductive cloning in animals, the report concludes that human reproductive cloning would be dangerous for the woman, fetus, and newborn, and is likely to fail. The study panel did not address the issue of whether human reproductive cloning, even if it were found to be medically safe, would beâ€or would not beâ€acceptable to individuals or society. |
| definition of somatic in biology: Principles of Developmental Genetics Sally A. Moody, 2007-07-19 Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology.• Includes new research not previously published in any other book on the molecular geneticprocesses that regulates development• Chapters present a broad understanding on the application of animal model systems, allowingresearchers to better treat clinical disorders and comprehend human development• Relates the application of new technologies to the manipulation of stem cells, causes ofhuman birth defects, and several human disease conditions• Each chapter includes a bulleted summary highlighting clinical aspects of animal models |
| definition of somatic in biology: Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics Reed E. Pyeritz, Bruce R. Korf, Wayne W. Grody, 2024-10-23 For decades, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics and genomics into medical practice. With detailed coverage in contributions from more than 250 of the world's most trusted authorities in medical genetics and a series of 11 volumes available for individual sale, the Seventh Edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome sequencing, public health genetics, genetic counseling, and management and treatment strategies to complete its coverage of this growing field for students, health providers, and researchers involved in the care of patients with genetic conditions, and increasingly, all areas of health and disease. This comprehensive yet practical resource emphasizes theory and research fundamentals related to the applications of medical genetics and genomics across the full spectrum of inherited disorders and applications to medicine more broadly. In this volume, leading physicians and researchers thoroughly examine medical genetics and genomics as applied to developmental disorders, as well as genetic conditions that affect hearing and vision. Here genetic researchers, students, and health professionals will find new and fully revised chapters on human developmental genetics, disorders affecting craniofacial development, chromosomal abnormalities, including aneuploidies and structural abnormalities, hereditary hearing impairment, and various genetic conditions of the eye. With regular advances in genomic technologies propelling precision medicine into the clinic, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics, Seventh Edition bridges the gap between high-level molecular genetics and practical application and serves as an invaluable clinical tool for health professionals and researchers. · Thoroughly introduces genetic researchers, students, and healthcare professionals to the principles of human developmental genetics · Examines a wide range of developmental disorders, including craniofacial development as well as disorders affecting hearing and vision · Includes color images supporting identification, concept illustration, and method processing · Features contributions by leading international researchers and practitioners of medical genetics |
| definition of somatic in biology: Concepts of Biology Samantha Fowler, Rebecca Roush, James Wise, 2023-05-12 Black & white print. Concepts of Biology is designed for the typical introductory biology course for nonmajors, covering standard scope and sequence requirements. The text includes interesting applications and conveys the major themes of biology, with content that is meaningful and easy to understand. The book is designed to demonstrate biology concepts and to promote scientific literacy. |
| definition of somatic in biology: Human Genome Editing National Academies of Sciences, Engineering, and Medicine, National Academy of Medicine, National Academy of Sciences, Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations, 2017-08-13 Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing. |
| definition of somatic in biology: Modern Applications of Plant Biotechnology in Pharmaceutical Sciences Saurabh Bhatia, Kiran Sharma, Randhir Dahiya, Tanmoy Bera, 2015-07-22 Modern Applications of Plant Biotechnology in Pharmaceutical Sciences explores advanced techniques in plant biotechnology, their applications to pharmaceutical sciences, and how these methods can lead to more effective, safe, and affordable drugs. The book covers modern approaches in a practical, step-by-step manner, and includes illustrations, examples, and case studies to enhance understanding. Key topics include plant-made pharmaceuticals, classical and non-classical techniques for secondary metabolite production in plant cell culture and their relevance to pharmaceutical science, edible vaccines, novel delivery systems for plant-based products, international industry regulatory guidelines, and more. Readers will find the book to be a comprehensive and valuable resource for the study of modern plant biotechnology approaches and their pharmaceutical applications. - Builds upon the basic concepts of cell and plant tissue culture and recombinant DNA technology to better illustrate the modern and potential applications of plant biotechnology to the pharmaceutical sciences - Provides detailed yet practical coverage of complex techniques, such as micropropogation, gene transfer, and biosynthesis - Examines critical issues of international importance and offers real-life examples and potential solutions |
| definition of somatic in biology: Somatic Gene Therapy P.L. Chang, 2018-01-17 As human gene therapy becomes a clinical reality, a new era in medicine dawns. Novel and innovative developments in molecular genetics now provide opportunities to treat the genetic bases of diseases often untreatable before. Somatic Gene Therapy documents these historical clinical trials, reviews current advances in the field, evaluates the use of the many different cell types and organs amenable to gene transfer, and examines the prospects of various exciting strategies for gene therapy. |
| definition of somatic in biology: The Biology of Reproduction Giuseppe Fusco, Alessandro Minelli, 2019-10-10 A look into the phenomena of sex and reproduction in all organisms, taking an innovative, unified and comprehensive approach. |
| definition of somatic in biology: The Cell: A Very Short Introduction Terence Allen, Terence David Allen, Graham Cowling, 2011-09-29 Introduces cells, discussing their structure, life cycle, and what they can do. |
| definition of somatic in biology: Anatomy and Physiology J. Gordon Betts, Peter DeSaix, Jody E. Johnson, Oksana Korol, Dean H. Kruse, Brandon Poe, James A. Wise, Mark Womble, Kelly A. Young, 2013-04-25 |
| definition of somatic in biology: Stem Cells in Reproductive Medicine Carlos Simón, Antonio Pellicer, Renee Reijo Pera, 2013-07-04 Stem cell science has the potential to impact human reproductive medicine significantly - cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research. The book is essential reading for reproductive medicine clinicians, gynecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field. |
| definition of somatic in biology: Epigenetics and Regeneration , 2019-05-24 Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. - Provides a foundational overview of epigenetics in regenerative medicine - Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice - Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways - Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine |
| definition of somatic in biology: Biology for AP ® Courses Julianne Zedalis, John Eggebrecht, 2017-10-16 Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences. |
| definition of somatic in biology: The Germ-plasm August Weismann, 1893 |
| definition of somatic in biology: Stem Cell Biology Daniel R. Marshak, Richard Lavenham Gardner, David I. Gottlieb, 2001 Stem cells are the focus of intense interest from a growing, multidisciplinary community of investigators with new tools for isolating and characterizing these elusive cell types. This volume, which features contributions from many of the world's leading laboratories, provides a uniquely broad and authoritative basis for understanding the biology of stem cells and the current excitement about their potential for clinical exploitation. It is an essential work of reference for investigators in embryology, hematology, and neurobiology, and their potential for clinical exploitation. It is an essential work of reference for investigators in embryology, hematology, and neurobiology, and their collaborators in the emerging field of regenerative medicine. |
| definition of somatic in biology: The Body: A Very Short Introduction Chris Shilling, 2016-01-28 The human body is thought of conventionally as a biological entity, with its longevity, morbidity, size and even appearance determined by genetic factors immune to the influence of society or culture. Since the mid-1980s, however, there has been a rising awareness of how our bodies, and our perception of them, are influenced by the social, cultural and material contexts in which humans live. Drawing on studies of sex and gender, education, governance, the economy, and religion, Chris Shilling demonstrates how our physical being allows us to affect the material and virtual world around us, yet also enables governments to shape and direct our thoughts and actions. Revealing how social relationships, cultural images, and technological and medical advances shape our perceptions and awareness, he exposes the limitations of traditional Western traditions of thought that elevate the mind over the body as that which defines us as human. Dealing with issues ranging from cosmetic and transplant surgery, the performance of gendered identities, the commodification of bodies and body parts, and the violent consequences of competing conceptions of the body as sacred, Shilling provides a compelling account of why body matters present contemporary societies with a series of urgent and inescapable challenges. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable. |
| definition of somatic in biology: Meiosis and Gametogenesis , 1997-11-24 In spite of the fact that the process of meiosis is fundamental to inheritance, surprisingly little is understood about how it actually occurs. There has recently been a flurry of research activity in this area and this volume summarizes the advances coming from this work. All authors are recognized and respected research scientists at the forefront of research in meiosis. Of particular interest is the emphasis in this volume on meiosis in the context of gametogenesis in higher eukaryotic organisms, backed up by chapters on meiotic mechanisms in other model organisms. The focus is on modern molecular and cytological techniques and how these have elucidated fundamental mechanisms of meiosis. Authors provide easy access to the literature for those who want to pursue topics in greater depth, but reviews are comprehensive so that this book may become a standard reference.Key Features* Comprehensive reviews that, taken together, provide up-to-date coverage of a rapidly moving field* Features new and unpublished information* Integrates research in diverse organisms to present an overview of common threads in mechanisms of meiosis* Includes thoughtful consideration of areas for future investigation |
| definition of somatic in biology: Somatic Cell Genetics Richard L. Davidson, 1984 |
| definition of somatic in biology: Distant Hybridization of Crop Plants G. Kalloo, J.B. Chowdhury, 2012-12-06 Wild taxa are invaluable sources of resistance to diseases, insects/ pests, nematodes, temperature extremes, salinity and alkalinity stresses, and also of nutritional quality; adaptation; genetic diversity and new species. Utilization of wild relatives of a crop depends largely upon its crossability relations with cultivated varieties. Sev eral wild species are not crossable with the commercial cultivars due to various isolation barriers. Furthermore, in a few cases, hybridiza tion is possible only in one direction and reciprocal crosses are not successful, thus depriving the utilization of desired cytoplasm of many species. However, techniques have been developed to over come many barriers and hybrid plants are produced. New crop species have been developed by overcoming the F 1 sterility and producing amphidiploids and such crops are commercially being grown in the field. The segregation pattern ofF 1 hybrids produced by distant hybridization in segregating generations are different from the intervarietal hybrids. In former cases, generally, unidirectional segregation takes place in early generations and accordingly, selec tion procedures are adopted. In most of the cases, backcross or modified backcross methods have been followed to utilize wild species, and thus numerous types of resistance and other economical attributes have been transferred in the recurrent parents. Protoplast fusion has been amply demonstrated in a number of cases where sexual hybridization was not possible and, as a result, hybrids have been produced. |
| definition of somatic in biology: Cellular And Molecular Biology For Human S.S. Guraya, 2007-12 Summarizes and integrates the results obtained on the study ovarian components with the techniques like electron microscopy and histochemistry in order to provide an insight into the basic subcellular, and molecular aspects of human primordial follicles, oogenesis (oocyte growth and maturation), ovulation, fertilization and early embryogenesis. |
| definition of somatic in biology: Genomics, Circuits, and Pathways in Clinical Neuropsychiatry Thomas Lehner, Bruce L. Miller, Matthew W. State, 2016-06-07 This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. - Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics - Identifies key concepts, methods, and findings - Includes coverage of multiple disorders from autism to schizophrenia - Reviews specific genes associated with disorders - Discusses the genetic architecture of these syndromes - Explains how recent findings are influencing the understanding of biology - Clarifies the promise of these findings for future treatment |
| definition of somatic in biology: Principles of Cloning Jose Cibelli, Ian Wilmut, Rudolf Jaenisch, John Gurdon, Robert Lanza, Michael West, Keith H.S. Campbell, 2013-09-24 Principles of Cloning, Second Edition is the fully revised edition of the authoritative book on the science of cloning. The book presents the basic biological mechanisms of how cloning works and progresses to discuss current and potential applications in basic biology, agriculture, biotechnology, and medicine. Beginning with the history and theory behind cloning, the book goes on to examine methods of micromanipulation, nuclear transfer, genetic modification, and pregnancy and neonatal care of cloned animals. The cloning of various species—including mice, sheep, cattle, and non-mammals—is considered as well. The Editors have been involved in a number of breakthroughs using cloning technique, including the first demonstration that cloning works in differentiated cells done by the Recipient of the 2012 Nobel Prize for Physiology or Medicine – Dr John Gurdon; the cloning of the first mammal from a somatic cell – Drs Keith Campbell and Ian Wilmut; the demonstration that cloning can reset the biological clock - Drs Michael West and Robert Lanza; the demonstration that a terminally differentiated cell can give rise to a whole new individual – Dr Rudolf Jaenisch and the cloning of the first transgenic bovine from a differentiated cell – Dr Jose Cibelli. The majority of the contributing authors are the principal investigators on each of the animal species cloned to date and are expertly qualified to present the state-of-the-art information in their respective areas. - First and most comprehensive book on animal cloning, 100% revised - Describes an in-depth analysis of current limitations of the technology and research areas to explore - Offers cloning applications on basic biology, agriculture, biotechnology, and medicine |
| definition of somatic in biology: Encyclopedia of Cardiovascular Research and Medicine , 2017-11-27 Encyclopedia of Cardiovascular Research and Medicine, Four Volume Set offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine. Presents comprehensive coverage of every aspect of cardiovascular medicine and research Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables. |
| definition of somatic in biology: The Evolution of Senescence in the Tree of Life Richard P. Shefferson, Owen R. Jones, Roberto Salguero-Gómez, 2017-02-23 Top researchers in the field introduce interdisciplinary perspectives on senescence, presenting new insights and cutting-edge research. |
| definition of somatic in biology: Functional Somatic Symptoms in Children and Adolescents Kasia Kozlowska, Stephen Scher, Helene Helgeland, 2020-09-30 This open access book sets out the stress-system model for functional somatic symptoms in children and adolescents. The book begins by exploring the initial encounter between the paediatrician, child, and family, moves through the assessment process, including the formulation and the treatment contract, and then describes the various forms of treatment that are designed to settle the child’s dysregulated stress system. This approach both provides a new understanding of how such symptoms emerge – typically, through a history of recurrent or chronic stress, either physical or psychological – and points the way to effective assessment, management, and treatment that put the child (and family) back on the road to health and well-being. |
| definition of somatic in biology: Healing Trauma Peter A. Levine, 2008 Medical researchers have known for decades that survivors of accidents, disaster, and childhood trauma often endure life-long symptoms ranging from anxiety and depression to unexplained physical pain and harmful acting out behaviors. Drawing on nature's lessons, Dr. Levine teaches you each of the essential principles of his four-phase process: you will learn how and where you are storing unresolved distress; how to become more aware of your body's physiological responses to danger; and specific methods to free yourself from trauma. |
| definition of somatic in biology: Cell Biology by the Numbers Ron Milo, Rob Phillips, 2015-12-07 A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid |
| definition of somatic in biology: The Biology of Senescence Alex Comfort, Alex Comfort, M.D., D.SC., 2010-11-25 The Biology of Senescence |
| definition of somatic in biology: Molecular Biology of B Cells Tasuku Honjo, Michael Reth, Andreas Radbruch, Frederick Alt, 2014-12-22 Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. |
| definition of somatic in biology: The Plant Cell Cycle Dirk Inzé, 2011-06-27 In recent years, the study of the plant cell cycle has become of major interest, not only to scientists working on cell division sensu strictu , but also to scientists dealing with plant hormones, development and environmental effects on growth. The book The Plant Cell Cycle is a very timely contribution to this exploding field. Outstanding contributors reviewed, not only knowledge on the most important classes of cell cycle regulators, but also summarized the various processes in which cell cycle control plays a pivotal role. The central role of the cell cycle makes this book an absolute must for plant molecular biologists. |
| definition of somatic in biology: Hereditary Effects of Radiation United Nations. Scientific Committee on the Effects of Atomic Radiation, 2001 The 2001 report completed a comprehensive review of the risks to offspring following parental exposure to radiation. The review included an evaluation of those diseases which have both hereditary and environmental components. The major finding is that the total hereditary risk to the first generation following radiation is less than one tenth of the risk of fatal carcinogenesis following irrradiation. The Committee concluded that a sounder basis now exists for estimating the hereditary risks of radiation exposure. This is due to advances in molecular genetics, and in the evaluation of multifactorial diseases, such as coronary heart disease. |
| definition of somatic in biology: The Genetics of Cancer B.A. Ponder, M.J. Waring, 2012-12-06 It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications. |
| definition of somatic in biology: The Interneuron Mary A. B. Brazier, 2023-11-10 |
| definition of somatic in biology: The Molecular Basis of Cancer John Mendelsohn, Peter M. Howley, Mark A. Israel, Joe W. Gray, Craig B. Thompson, 2008-04-01 Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances. |
| definition of somatic in biology: The Cell Cycle and Cancer Renato Baserga, 1971 |
| definition of somatic in biology: A History of Genetics Alfred Henry Sturtevant, 2001 In the small “Fly Room†at Columbia University, T.H. Morgan and his students, A.H. Sturtevant, C.B. Bridges, and H.J. Muller, carried out the work that laid the foundations of modern, chromosomal genetics. The excitement of those times, when the whole field of genetics was being created, is captured in this book, written in 1965 by one of those present at the beginning. His account is one of the few authoritative, analytic works on the early history of genetics. This attractive reprint is accompanied by a website, http://www.esp.org/books/sturt/history/ offering full-text versions of the key papers discussed in the book, including the world's first genetic map. |
| definition of somatic in biology: The Neuroscience of Emotion Ralph Adolphs, David J. Anderson, 2018-06-05 A new framework for the neuroscientific study of emotions in humans and animals The Neuroscience of Emotion presents a new framework for the neuroscientific study of emotion across species. Written by Ralph Adolphs and David J. Anderson, two leading authorities on the study of emotion, this accessible and original book recasts the discipline and demonstrates that in order to understand emotion, we need to examine its biological roots in humans and animals. Only through a comparative approach that encompasses work at the molecular, cellular, systems, and cognitive levels will we be able to comprehend what emotions do, how they evolved, how the brain shapes their development, and even how we might engineer them into robots in the future. Showing that emotions are ubiquitous across species and implemented in specific brain circuits, Adolphs and Anderson offer a broad foundation for thinking about emotions as evolved, functionally defined biological states. The authors discuss the techniques and findings from modern neuroscientific investigations of emotion and conclude with a survey of theories and future research directions. Featuring color illustrations throughout, The Neuroscience of Emotion synthesizes the latest in neuroscientific work to provide deeper insights into how emotions function in all of us. |
